diff --git a/start.py b/start.py
index 74cf4772d0..b5e0fee847 100644
--- a/start.py
+++ b/start.py
@@ -119,6 +119,26 @@ bootstrap = BootstrapRepos()
 silent_commands = ["run", "igniter", "standalonepublisher"]
 
 
+def set_pype_global_environments() -> None:
+    """Set global pype's environments."""
+    import acre
+
+    from pype.settings import get_environments
+
+    all_env = get_environments()
+
+    # TODO Global environments will be stored in "general" settings so loading
+    #   will be modified and can be done in igniter.
+    env = acre.merge(all_env["global"], dict(os.environ))
+    os.environ.clear()
+    os.environ.update(env)
+
+    # Hardcoded default values
+    os.environ["PYBLISH_GUI"] = "pyblish_pype"
+    # Change scale factor only if is not set
+    if "QT_AUTO_SCREEN_SCALE_FACTOR" not in os.environ:
+        os.environ["QT_AUTO_SCREEN_SCALE_FACTOR"] = "1"
+
 
 def run(arguments: list, env: dict = None) -> int:
     """Use correct executable to run stuff.
@@ -591,9 +611,11 @@ def boot():
     from pype.lib import terminal as t
     from pype.version import __version__
     print(">>> loading environments ...")
-    # Must happen before `set_modules_environments`
+    # Avalon environments must be set before avalon module is imported
     print("  - for Avalon ...")
     set_avalon_environments()
+    print("  - global Pype ...")
+    set_pype_global_environments()
     print("  - for modules ...")
     set_modules_environments()