diff --git a/openpype/hosts/maya/plugins/publish/validate_look_color_space.py b/openpype/hosts/maya/plugins/publish/validate_look_color_space.py
new file mode 100644
index 0000000000..05a10fd9f6
--- /dev/null
+++ b/openpype/hosts/maya/plugins/publish/validate_look_color_space.py
@@ -0,0 +1,25 @@
+from maya import cmds
+
+import pyblish.api
+from openpype.pipeline.publish import ValidateContentsOrder
+
+
+class ValidateMayaColorSpace(pyblish.api.InstancePlugin):
+    """
+        Check if the OCIO Color Management and maketx options
+        enabled at the same time
+    """
+
+    order = ValidateContentsOrder
+    families = ['look']
+    hosts = ['maya']
+    label = 'Maya Color Space'
+
+    def process(self, instance):
+        ocio_maya = cmds.colorManagementPrefs(q=True,
+                                              cmConfigFileEnabled=True,
+                                              cmEnabled=True)
+        maketx = instance.data["maketx"]
+
+        if ocio_maya and maketx:
+            raise Exception("Maya is color managed and maketx option is on. OpenPype doesn't support this combination yet.") # noqa
diff --git a/openpype/settings/defaults/project_settings/maya.json b/openpype/settings/defaults/project_settings/maya.json
index 5f40c2a10c..21815278a8 100644
--- a/openpype/settings/defaults/project_settings/maya.json
+++ b/openpype/settings/defaults/project_settings/maya.json
@@ -306,6 +306,11 @@
             "optional": true,
             "active": true
         },
+        "ValidateMayaColorSpace": {
+            "enabled": true,
+            "optional": true,
+            "active": true
+        },
         "ValidateAttributes": {
             "enabled": false,
             "attributes": {}
diff --git a/openpype/settings/entities/schemas/projects_schema/schemas/schema_maya_publish.json b/openpype/settings/entities/schemas/projects_schema/schemas/schema_maya_publish.json
index 9aaff248ab..a920d5aeae 100644
--- a/openpype/settings/entities/schemas/projects_schema/schemas/schema_maya_publish.json
+++ b/openpype/settings/entities/schemas/projects_schema/schemas/schema_maya_publish.json
@@ -144,6 +144,10 @@
                 {
                     "key": "ValidateShadingEngine",
                     "label": "Validate Look Shading Engine Naming"
+                },
+                {
+                    "key": "ValidateMayaColorSpace",
+                    "label": "ValidateMayaColorSpace"
                 }
             ]
         },