diff --git a/pype/modules/avalon_apps/avalon_app.py b/pype/modules/avalon_apps/avalon_app.py
index 38d6e4394c..60f62fe731 100644
--- a/pype/modules/avalon_apps/avalon_app.py
+++ b/pype/modules/avalon_apps/avalon_app.py
@@ -23,7 +23,7 @@ class AvalonModule(PypeModule, ITrayModule, IWebServerRoutes):
             avalon_mongo_url = avalon_settings["AVALON_MONGO"]
         # Use pype mongo if Avalon's mongo not defined
         if not avalon_mongo_url:
-            avalon_mongo_url = os.environ["PYPE_MONGO"]
+            avalon_mongo_url = os.environ["OPENPYPE_MONGO"]
 
         thumbnail_root = os.environ.get("AVALON_THUMBNAIL_ROOT")
         if not thumbnail_root:
diff --git a/pype/modules/deadline/plugins/publish/submit_aftereffects_deadline.py b/pype/modules/deadline/plugins/publish/submit_aftereffects_deadline.py
index c1a6de4ce3..5ec5129fa4 100644
--- a/pype/modules/deadline/plugins/publish/submit_aftereffects_deadline.py
+++ b/pype/modules/deadline/plugins/publish/submit_aftereffects_deadline.py
@@ -64,9 +64,9 @@ class AfterEffectsSubmitDeadline(abstract_submit_deadline.AbstractSubmitDeadline
             "AVALON_ASSET",
             "AVALON_TASK",
             "AVALON_APP_NAME",
-            "PYPE_USERNAME",
-            "PYPE_DEV",
-            "PYPE_LOG_NO_COLORS"
+            "OPENPYPE_USERNAME",
+            "OPENPYPE_DEV",
+            "OPENPYPE_LOG_NO_COLORS"
         ]
 
         environment = dict({key: os.environ[key] for key in keys
@@ -78,7 +78,7 @@ class AfterEffectsSubmitDeadline(abstract_submit_deadline.AbstractSubmitDeadline
                      key=key,
                      value=val)
         # to recognize job from PYPE for turning Event On/Off
-        dln_job_info.EnvironmentKeyValue = "PYPE_RENDER_JOB=1"
+        dln_job_info.EnvironmentKeyValue = "OPENPYPE_RENDER_JOB=1"
 
         return dln_job_info
 
diff --git a/pype/modules/deadline/plugins/publish/submit_harmony_deadline..py b/pype/modules/deadline/plugins/publish/submit_harmony_deadline..py
index 8e85937353..d723490a69 100644
--- a/pype/modules/deadline/plugins/publish/submit_harmony_deadline..py
+++ b/pype/modules/deadline/plugins/publish/submit_harmony_deadline..py
@@ -273,9 +273,9 @@ class HarmonySubmitDeadline(
             "AVALON_ASSET",
             "AVALON_TASK",
             "AVALON_APP_NAME",
-            "PYPE_USERNAME",
-            "PYPE_DEV",
-            "PYPE_LOG_NO_COLORS"
+            "OPENPYPE_USERNAME",
+            "OPENPYPE_DEV",
+            "OPENPYPE_LOG_NO_COLORS"
         ]
 
         environment = dict({key: os.environ[key] for key in keys
@@ -288,7 +288,7 @@ class HarmonySubmitDeadline(
                     value=val)
 
         # to recognize job from PYPE for turning Event On/Off
-        job_info.EnvironmentKeyValue = "PYPE_RENDER_JOB=1"
+        job_info.EnvironmentKeyValue = "OPENPYPE_RENDER_JOB=1"
 
         return job_info
 
diff --git a/pype/modules/deadline/plugins/publish/submit_maya_deadline.py b/pype/modules/deadline/plugins/publish/submit_maya_deadline.py
index b17dd6ba8d..041a351de9 100644
--- a/pype/modules/deadline/plugins/publish/submit_maya_deadline.py
+++ b/pype/modules/deadline/plugins/publish/submit_maya_deadline.py
@@ -441,17 +441,17 @@ class MayaSubmitDeadline(pyblish.api.InstancePlugin):
             "AVALON_ASSET",
             "AVALON_TASK",
             "AVALON_APP_NAME",
-            "PYPE_USERNAME",
-            "PYPE_DEV",
-            "PYPE_LOG_NO_COLORS"
+            "OPENPYPE_USERNAME",
+            "OPENPYPE_DEV",
+            "OPENPYPE_LOG_NO_COLORS"
         ]
 
         environment = dict({key: os.environ[key] for key in keys
                             if key in os.environ}, **api.Session)
-        environment["PYPE_LOG_NO_COLORS"] = "1"
-        environment["PYPE_MAYA_VERSION"] = cmds.about(v=True)
+        environment["OPENPYPE_LOG_NO_COLORS"] = "1"
+        environment["OPENPYPE_MAYA_VERSION"] = cmds.about(v=True)
         # to recognize job from PYPE for turning Event On/Off
-        environment["PYPE_RENDER_JOB"] = "1"
+        environment["OPENPYPE_RENDER_JOB"] = "1"
         self.payload_skeleton["JobInfo"].update({
             "EnvironmentKeyValue%d" % index: "{key}={value}".format(
                 key=key,
@@ -858,20 +858,20 @@ class MayaSubmitDeadline(pyblish.api.InstancePlugin):
         envs.append(
             "AVALON_APP_NAME={}".format(os.environ.get("AVALON_APP_NAME")))
         envs.append(
-            "PYPE_ASS_EXPORT_RENDER_LAYER={}".format(data["renderlayer"]))
+            "OPENPYPE_ASS_EXPORT_RENDER_LAYER={}".format(data["renderlayer"]))
         envs.append(
-            "PYPE_ASS_EXPORT_SCENE_FILE={}".format(data["filepath"]))
+            "OPENPYPE_ASS_EXPORT_SCENE_FILE={}".format(data["filepath"]))
         envs.append(
-            "PYPE_ASS_EXPORT_OUTPUT={}".format(
+            "OPENPYPE_ASS_EXPORT_OUTPUT={}".format(
                 payload['JobInfo']['OutputFilename0']))
         envs.append(
-            "PYPE_ASS_EXPORT_START={}".format(
+            "OPENPYPE_ASS_EXPORT_START={}".format(
                 int(self._instance.data["frameStartHandle"])))
         envs.append(
-            "PYPE_ASS_EXPORT_END={}".format(
+            "OPENPYPE_ASS_EXPORT_END={}".format(
                 int(self._instance.data["frameEndHandle"])))
         envs.append(
-            "PYPE_ASS_EXPORT_STEP={}".format(1))
+            "OPENPYPE_ASS_EXPORT_STEP={}".format(1))
 
         i = 0
         for e in envs:
@@ -984,7 +984,7 @@ class MayaSubmitDeadline(pyblish.api.InstancePlugin):
 
         """
         if 'verify' not in kwargs:
-            kwargs['verify'] = False if os.getenv("PYPE_DONT_VERIFY_SSL", True) else True  # noqa
+            kwargs['verify'] = False if os.getenv("OPENPYPE_DONT_VERIFY_SSL", True) else True  # noqa
         # add 10sec timeout before bailing out
         kwargs['timeout'] = 10
         return requests.post(*args, **kwargs)
@@ -1003,7 +1003,7 @@ class MayaSubmitDeadline(pyblish.api.InstancePlugin):
 
         """
         if 'verify' not in kwargs:
-            kwargs['verify'] = False if os.getenv("PYPE_DONT_VERIFY_SSL", True) else True  # noqa
+            kwargs['verify'] = False if os.getenv("OPENPYPE_DONT_VERIFY_SSL", True) else True  # noqa
         # add 10sec timeout before bailing out
         kwargs['timeout'] = 10
         return requests.get(*args, **kwargs)
diff --git a/pype/modules/deadline/plugins/publish/submit_nuke_deadline.py b/pype/modules/deadline/plugins/publish/submit_nuke_deadline.py
index a4653427bb..2e30e624ef 100644
--- a/pype/modules/deadline/plugins/publish/submit_nuke_deadline.py
+++ b/pype/modules/deadline/plugins/publish/submit_nuke_deadline.py
@@ -237,7 +237,7 @@ class NukeSubmitDeadline(pyblish.api.InstancePlugin):
             "PYBLISHPLUGINPATH",
             "NUKE_PATH",
             "TOOL_ENV",
-            "PYPE_DEV",
+            "OPENPYPE_DEV",
             "FOUNDRY_LICENSE"
         ]
         environment = dict({key: os.environ[key] for key in keys
@@ -279,7 +279,7 @@ class NukeSubmitDeadline(pyblish.api.InstancePlugin):
 
         environment = clean_environment
         # to recognize job from PYPE for turning Event On/Off
-        environment["PYPE_RENDER_JOB"] = "1"
+        environment["OPENPYPE_RENDER_JOB"] = "1"
         payload["JobInfo"].update({
             "EnvironmentKeyValue%d" % index: "{key}={value}".format(
                 key=key,
diff --git a/pype/modules/deadline/plugins/publish/submit_publish_job.py b/pype/modules/deadline/plugins/publish/submit_publish_job.py
index 38d328b1cb..8f937b23df 100644
--- a/pype/modules/deadline/plugins/publish/submit_publish_job.py
+++ b/pype/modules/deadline/plugins/publish/submit_publish_job.py
@@ -114,16 +114,16 @@ class ProcessSubmittedJobOnFarm(pyblish.api.InstancePlugin):
         "FTRACK_API_USER",
         "FTRACK_API_KEY",
         "FTRACK_SERVER",
-        "PYPE_METADATA_FILE",
+        "OPENPYPE_METADATA_FILE",
         "AVALON_PROJECT",
         "AVALON_ASSET",
         "AVALON_TASK",
         "AVALON_APP_NAME",
-        "PYPE_PUBLISH_JOB"
-        "PYPE_LOG_NO_COLORS",
-        "PYPE_USERNAME",
-        "PYPE_RENDER_JOB",
-        "PYPE_PUBLISH_JOB"
+        "OPENPYPE_PUBLISH_JOB"
+        "OPENPYPE_LOG_NO_COLORS",
+        "OPENPYPE_USERNAME",
+        "OPENPYPE_RENDER_JOB",
+        "OPENPYPE_PUBLISH_JOB"
     ]
 
     # custom deadline atributes
@@ -223,10 +223,10 @@ class ProcessSubmittedJobOnFarm(pyblish.api.InstancePlugin):
         environment["AVALON_ASSET"] = io.Session["AVALON_ASSET"]
         environment["AVALON_TASK"] = io.Session["AVALON_TASK"]
         environment["AVALON_APP_NAME"] = os.environ.get("AVALON_APP_NAME")
-        environment["PYPE_LOG_NO_COLORS"] = "1"
-        environment["PYPE_USERNAME"] = instance.context.data["user"]
-        environment["PYPE_PUBLISH_JOB"] = "1"
-        environment["PYPE_RENDER_JOB"] = "0"
+        environment["OPENPYPE_LOG_NO_COLORS"] = "1"
+        environment["OPENPYPE_USERNAME"] = instance.context.data["user"]
+        environment["OPENPYPE_PUBLISH_JOB"] = "1"
+        environment["OPENPYPE_RENDER_JOB"] = "0"
 
         args = [
             'publish',
@@ -1048,4 +1048,4 @@ class ProcessSubmittedJobOnFarm(pyblish.api.InstancePlugin):
             # Directory
             publish_folder = os.path.dirname(file_path)
 
-        return publish_folder
\ No newline at end of file
+        return publish_folder
diff --git a/pype/modules/deadline/plugins/publish/validate_deadline_connection.py b/pype/modules/deadline/plugins/publish/validate_deadline_connection.py
index 1c49e68ee1..88b3f42d49 100644
--- a/pype/modules/deadline/plugins/publish/validate_deadline_connection.py
+++ b/pype/modules/deadline/plugins/publish/validate_deadline_connection.py
@@ -44,5 +44,5 @@ class ValidateDeadlineConnection(pyblish.api.ContextPlugin):
             of defense SSL is providing and it is not recommended.
         """
         if 'verify' not in kwargs:
-            kwargs['verify'] = False if os.getenv("PYPE_DONT_VERIFY_SSL", True) else True  # noqa
+            kwargs['verify'] = False if os.getenv("OPENPYPE_DONT_VERIFY_SSL", True) else True  # noqa
         return requests.get(*args, **kwargs)
diff --git a/pype/modules/ftrack/event_handlers_user/action_applications.py b/pype/modules/ftrack/event_handlers_user/action_applications.py
index 2c42cadfb7..fcfebe5078 100644
--- a/pype/modules/ftrack/event_handlers_user/action_applications.py
+++ b/pype/modules/ftrack/event_handlers_user/action_applications.py
@@ -26,7 +26,7 @@ class AppplicationsAction(BaseAction):
     type = "Application"
     label = "Application action"
     identifier = "pype_app.{}.".format(str(uuid4()))
-    icon_url = os.environ.get("PYPE_STATICS_SERVER")
+    icon_url = os.environ.get("OPENPYPE_STATICS_SERVER")
 
     def __init__(self, *args, **kwargs):
         super().__init__(*args, **kwargs)
diff --git a/pype/modules/ftrack/ftrack_server/socket_thread.py b/pype/modules/ftrack/ftrack_server/socket_thread.py
index a895e0b900..181fad5ce5 100644
--- a/pype/modules/ftrack/ftrack_server/socket_thread.py
+++ b/pype/modules/ftrack/ftrack_server/socket_thread.py
@@ -12,7 +12,7 @@ from pype.lib import get_pype_execute_args
 class SocketThread(threading.Thread):
     """Thread that checks suprocess of storer of processor of events"""
 
-    MAX_TIMEOUT = int(os.environ.get("PYPE_FTRACK_SOCKET_TIMEOUT", 45))
+    MAX_TIMEOUT = int(os.environ.get("OPENPYPE_FTRACK_SOCKET_TIMEOUT", 45))
 
     def __init__(self, name, port, filepath, additional_args=[]):
         super(SocketThread, self).__init__()
@@ -57,7 +57,7 @@ class SocketThread(threading.Thread):
         )
 
         env = os.environ.copy()
-        env["PYPE_PROCESS_MONGO_ID"] = str(Logger.mongo_process_id)
+        env["OPENPYPE_PROCESS_MONGO_ID"] = str(Logger.mongo_process_id)
         # Pype executable (with path to start script if not build)
         args = get_pype_execute_args(
             # Add `run` command
diff --git a/pype/modules/ftrack/lib/ftrack_action_handler.py b/pype/modules/ftrack/lib/ftrack_action_handler.py
index d95c81955e..2bff9d8cb3 100644
--- a/pype/modules/ftrack/lib/ftrack_action_handler.py
+++ b/pype/modules/ftrack/lib/ftrack_action_handler.py
@@ -3,7 +3,7 @@ from .ftrack_base_handler import BaseHandler
 
 
 def statics_icon(*icon_statics_file_parts):
-    statics_server = os.environ.get("PYPE_STATICS_SERVER")
+    statics_server = os.environ.get("OPENPYPE_STATICS_SERVER")
     if not statics_server:
         return None
     return "/".join((statics_server, *icon_statics_file_parts))
diff --git a/pype/modules/ftrack/plugins/publish/validate_custom_ftrack_attributes.py b/pype/modules/ftrack/plugins/publish/validate_custom_ftrack_attributes.py
index 03aa8844fd..549f48889d 100644
--- a/pype/modules/ftrack/plugins/publish/validate_custom_ftrack_attributes.py
+++ b/pype/modules/ftrack/plugins/publish/validate_custom_ftrack_attributes.py
@@ -8,7 +8,7 @@ class ValidateFtrackAttributes(pyblish.api.InstancePlugin):
 
     Attributes to be validated are specified in:
 
-        `$PYPE_CONFIG/presets/<host>/ftrack_attributes.json`
+        `$OPENPYPE_CONFIG/presets/<host>/ftrack_attributes.json`
 
     This is array (list) of checks in format:
     [
diff --git a/pype/modules/muster/muster.py b/pype/modules/muster/muster.py
index 5595ccff15..1a82926802 100644
--- a/pype/modules/muster/muster.py
+++ b/pype/modules/muster/muster.py
@@ -153,5 +153,5 @@ class MusterModule(PypeModule, ITrayModule, IWebServerRoutes):
             of defense SSL is providing and it is not recommended.
         """
         if 'verify' not in kwargs:
-            kwargs['verify'] = False if os.getenv("PYPE_DONT_VERIFY_SSL", True) else True  # noqa
+            kwargs['verify'] = False if os.getenv("OPENPYPE_DONT_VERIFY_SSL", True) else True  # noqa
         return requests.post(*args, **kwargs)
diff --git a/pype/modules/timers_manager/timers_manager.py b/pype/modules/timers_manager/timers_manager.py
index b83f51f0ba..a8ea5799e6 100644
--- a/pype/modules/timers_manager/timers_manager.py
+++ b/pype/modules/timers_manager/timers_manager.py
@@ -221,7 +221,7 @@ class TimersManager(PypeModule, ITrayService, IIdleManager, IWebServerRoutes):
 
     def change_timer_from_host(self, project_name, asset_name, task_name):
         """Prepared method for calling change timers on REST api"""
-        webserver_url = os.environ.get("PYPE_WEBSERVER_URL")
+        webserver_url = os.environ.get("OPENPYPE_WEBSERVER_URL")
         if not webserver_url:
             self.log.warning("Couldn't find webserver url")
             return
diff --git a/pype/modules/user/user_module.py b/pype/modules/user/user_module.py
index 71c5fd124e..7d257f1781 100644
--- a/pype/modules/user/user_module.py
+++ b/pype/modules/user/user_module.py
@@ -29,7 +29,7 @@ class UserModule(PypeModule, ITrayModule, IWebServerRoutes):
         appdirs.user_data_dir('pype-app', 'pype')
     )
     cred_filename = 'user_info.json'
-    env_name = "PYPE_USERNAME"
+    env_name = "OPENPYPE_USERNAME"
 
     name = "user"
 
diff --git a/pype/modules/webserver/webserver_module.py b/pype/modules/webserver/webserver_module.py
index 3b3f0e7a79..b3fb83596d 100644
--- a/pype/modules/webserver/webserver_module.py
+++ b/pype/modules/webserver/webserver_module.py
@@ -49,8 +49,8 @@ class WebServerModule(PypeModule, ITrayService):
         self.server_manager.add_static(static_prefix, resources.RESOURCES_DIR)
 
         webserver_url = "http://localhost:{}".format(self.port)
-        os.environ["PYPE_WEBSERVER_URL"] = webserver_url
-        os.environ["PYPE_STATICS_SERVER"] = "{}{}".format(
+        os.environ["OPENPYPE_WEBSERVER_URL"] = webserver_url
+        os.environ["OPENPYPE_STATICS_SERVER"] = "{}{}".format(
             webserver_url, static_prefix
         )