diff --git a/openpype/hosts/flame/api/scripts/wiretap_com.py b/openpype/hosts/flame/api/scripts/wiretap_com.py
index 0cda25804b..4e54dfd913 100644
--- a/openpype/hosts/flame/api/scripts/wiretap_com.py
+++ b/openpype/hosts/flame/api/scripts/wiretap_com.py
@@ -9,31 +9,14 @@ import json
 import xml.dom.minidom as minidom
 from copy import deepcopy
 import datetime
-
-FLAME_V = os.getenv("OPENPYPE_FLAME_VERSION")
-
-if not FLAME_V:
-    raise KeyError("Missing key in environment `OPENPYPE_FLAME_VERSION`")
-
-try:
-    from libwiretapPythonClientAPI import (  # noqa
-        WireTapClientInit)
-except ImportError:
-    flame_python_path = "/opt/Autodesk/flame_{}/python".format(FLAME_V)
-    flame_exe_path = (
-        "/opt/Autodesk/flame_{}/bin/flame.app"
-        "/Contents/MacOS/startApp").format(FLAME_V)
-
-    sys.path.append(flame_python_path)
-
-    from libwiretapPythonClientAPI import (  # noqa
-        WireTapClientInit,
-        WireTapClientUninit,
-        WireTapNodeHandle,
-        WireTapServerHandle,
-        WireTapInt,
-        WireTapStr
-    )
+from libwiretapPythonClientAPI import (  # noqa
+    WireTapClientInit,
+    WireTapClientUninit,
+    WireTapNodeHandle,
+    WireTapServerHandle,
+    WireTapInt,
+    WireTapStr
+)
 
 
 class WireTapCom(object):
diff --git a/openpype/hosts/flame/hooks/pre_flame_setup.py b/openpype/hosts/flame/hooks/pre_flame_setup.py
index 512433b718..fc6b65c958 100644
--- a/openpype/hosts/flame/hooks/pre_flame_setup.py
+++ b/openpype/hosts/flame/hooks/pre_flame_setup.py
@@ -20,10 +20,8 @@ class FlamePrelaunch(PreLaunchHook):
     app_groups = ["flame"]
 
     # todo: replace version number with avalon launch app version
-    flame_python_exe = (
-        "/opt/Autodesk/python/{OPENPYPE_FLAME_VERSION}"
-        "/bin/python2.7"
-    )
+    flame_python_exe = os.getenv("OPENPYPE_FLAME_PYTHON_EXEC")
+    flame_pythonpath = os.getenv("OPENPYPE_FLAME_PYTHONPATH")
 
     wtc_script_path = os.path.join(
         opflame.HOST_DIR, "api", "scripts", "wiretap_com.py")
@@ -60,7 +58,6 @@ class FlamePrelaunch(PreLaunchHook):
             "FieldDominance": "PROGRESSIVE"
         }
 
-
         data_to_script = {
             # from settings
             "host_name": _env.get("FLAME_WIRETAP_HOSTNAME") or hostname,
@@ -77,12 +74,25 @@ class FlamePrelaunch(PreLaunchHook):
         self.log.info(pformat(dict(_env)))
         self.log.info(pformat(data_to_script))
 
+        # add to python path from settings
+        self._add_pythonpath()
+
         app_arguments = self._get_launch_arguments(data_to_script)
 
         opfapi.setup(self.launch_context.env)
 
         self.launch_context.launch_args.extend(app_arguments)
 
+    def _add_pythonpath(self):
+        pythonpath = self.launch_context.env.get("PYTHONPATH")
+
+        # separate it explicity by `;` that is what we use in settings
+        new_pythonpath = self.flame_pythonpath.split(";")
+        new_pythonpath += pythonpath.split(os.pathsep)
+
+        self.launch_context.env["PYTHONPATH"] = os.pathsep.join(new_pythonpath)
+
+
     def _get_launch_arguments(self, script_data):
         # Dump data to string
         dumped_script_data = json.dumps(script_data)
diff --git a/openpype/settings/defaults/system_settings/applications.json b/openpype/settings/defaults/system_settings/applications.json
index 3a097d2b37..7fe0432fdf 100644
--- a/openpype/settings/defaults/system_settings/applications.json
+++ b/openpype/settings/defaults/system_settings/applications.json
@@ -130,7 +130,8 @@
                     "linux": []
                 },
                 "environment": {
-                    "OPENPYPE_FLAME_VERSION": "2021"
+                    "OPENPYPE_FLAME_PYTHON_EXEC": "/opt/Autodesk/python/2021/bin/python2.7",
+                    "OPENPYPE_FLAME_PYTHONPATH": "/opt/Autodesk/flame_2021/python"
                 }
             },
             "__dynamic_keys_labels__": {