diff --git a/openpype/modules/ftrack/ftrack_module.py b/openpype/modules/ftrack/ftrack_module.py
index 0b0bbfc7e4..ee139a500e 100644
--- a/openpype/modules/ftrack/ftrack_module.py
+++ b/openpype/modules/ftrack/ftrack_module.py
@@ -133,10 +133,22 @@ class FtrackModule(
                 " Can't propagate changes to Ftrack server."
             ))
 
+        ftrack_changes = changes.get("modules", {}).get("ftrack", {})
+        url_change_msg = None
+        if "ftrack_server" in ftrack_changes:
+            url_change_msg = (
+                "Ftrack URL was changed."
+                " This change may need to restart OpenPype to take affect."
+            )
+
         try:
             session = self.create_ftrack_session()
         except Exception:
             self.log.warning("Couldn't create ftrack session.", exc_info=True)
+
+            if url_change_msg:
+                raise SaveWarningExc(url_change_msg)
+
             raise SaveWarningExc((
                 "Saving of attributes to ftrack wasn't successful,"
                 " try running Create/Update Avalon Attributes in ftrack."
@@ -210,6 +222,9 @@ class FtrackModule(
                 " Try running Create/Update Avalon Attributes in ftrack."
             ).format(", ".join(missing_attributes)))
 
+        if url_change_msg:
+            raise SaveWarningExc(url_change_msg)
+
     def on_project_settings_save(self, *_args, **_kwargs):
         """Implementation of ISettingsChangeListener interface."""
         # Ignore