diff --git a/openpype/hosts/maya/api/customize.py b/openpype/hosts/maya/api/customize.py
index 37fd543315..683e6b24b0 100644
--- a/openpype/hosts/maya/api/customize.py
+++ b/openpype/hosts/maya/api/customize.py
@@ -5,7 +5,7 @@ import logging
 
 from functools import partial
 
-import maya.cmds as mc
+import maya.cmds as cmds
 import maya.mel as mel
 
 from openpype.api import resources
@@ -30,9 +30,9 @@ def override_component_mask_commands():
     log.info("Installing override_component_mask_commands..")
 
     # Get all object mask buttons
-    buttons = mc.formLayout("objectMaskIcons",
-                            query=True,
-                            childArray=True)
+    buttons = cmds.formLayout("objectMaskIcons",
+                              query=True,
+                              childArray=True)
     # Skip the triangle list item
     buttons = [btn for btn in buttons if btn != "objPickMenuLayout"]
 
@@ -43,14 +43,14 @@ def override_component_mask_commands():
         # toggle the others based on whether any of the buttons
         # was remaining active after the toggle, if not then
         # enable all
-        if mc.getModifiers() == 4:  # = CTRL
+        if cmds.getModifiers() == 4:  # = CTRL
             state = True
-            active = [mc.iconTextCheckBox(btn, query=True, value=True) for btn
-                      in buttons]
+            active = [cmds.iconTextCheckBox(btn, query=True, value=True)
+                      for btn in buttons]
             if any(active):
-                mc.selectType(allObjects=False)
+                cmds.selectType(allObjects=False)
             else:
-                mc.selectType(allObjects=True)
+                cmds.selectType(allObjects=True)
 
         # Replace #1 with the current button state
         cmd = raw_command.replace(" #1", " {}".format(int(state)))
@@ -63,13 +63,13 @@ def override_component_mask_commands():
         # try to implement the fix. (This also allows us to
         # "uninstall" the behavior later)
         if btn not in COMPONENT_MASK_ORIGINAL:
-            original = mc.iconTextCheckBox(btn, query=True, cc=True)
+            original = cmds.iconTextCheckBox(btn, query=True, cc=True)
             COMPONENT_MASK_ORIGINAL[btn] = original
 
         # Assign the special callback
         original = COMPONENT_MASK_ORIGINAL[btn]
         new_fn = partial(on_changed_callback, original)
-        mc.iconTextCheckBox(btn, edit=True, cc=new_fn)
+        cmds.iconTextCheckBox(btn, edit=True, cc=new_fn)
 
 
 def override_toolbox_ui():
@@ -78,25 +78,36 @@ def override_toolbox_ui():
     parent_widget = get_main_window()
 
     # Ensure the maya web icon on toolbox exists
-    web_button = "ToolBox|MainToolboxLayout|mayaWebButton"
-    if not mc.iconTextButton(web_button, query=True, exists=True):
+    button_names = [
+        # Maya 2022.1+ with maya.cmds.iconTextStaticLabel
+        "ToolBox|MainToolboxLayout|mayaHomeToolboxButton",
+        # Older with maya.cmds.iconTextButton
+        "ToolBox|MainToolboxLayout|mayaWebButton"
+    ]
+    for name in button_names:
+        if cmds.control(name, query=True, exists=True):
+            web_button = name
+            break
+    else:
+        # Button does not exist
+        log.warning("Can't find Maya Home/Web button to override toolbox ui..")
         return
 
-    mc.iconTextButton(web_button, edit=True, visible=False)
+    cmds.control(web_button, edit=True, visible=False)
 
     # real = 32, but 36 with padding - according to toolbox mel script
     icon_size = 36
     parent = web_button.rsplit("|", 1)[0]
 
     # Ensure the parent is a formLayout
-    if not mc.objectTypeUI(parent) == "formLayout":
+    if not cmds.objectTypeUI(parent) == "formLayout":
         return
 
     # Create our controls
     controls = []
 
     controls.append(
-        mc.iconTextButton(
+        cmds.iconTextButton(
             "pype_toolbox_lookmanager",
             annotation="Look Manager",
             label="Look Manager",
@@ -109,7 +120,7 @@ def override_toolbox_ui():
     )
 
     controls.append(
-        mc.iconTextButton(
+        cmds.iconTextButton(
             "pype_toolbox_workfiles",
             annotation="Work Files",
             label="Work Files",
@@ -124,7 +135,7 @@ def override_toolbox_ui():
     )
 
     controls.append(
-        mc.iconTextButton(
+        cmds.iconTextButton(
             "pype_toolbox_loader",
             annotation="Loader",
             label="Loader",
@@ -139,7 +150,7 @@ def override_toolbox_ui():
     )
 
     controls.append(
-        mc.iconTextButton(
+        cmds.iconTextButton(
             "pype_toolbox_manager",
             annotation="Inventory",
             label="Inventory",
@@ -159,7 +170,7 @@ def override_toolbox_ui():
     for i, control in enumerate(controls):
         previous = controls[i - 1] if i > 0 else web_button
 
-        mc.formLayout(parent, edit=True,
-                      attachControl=[control, "bottom", 0, previous],
-                      attachForm=([control, "left", 1],
-                                  [control, "right", 1]))
+        cmds.formLayout(parent, edit=True,
+                        attachControl=[control, "bottom", 0, previous],
+                        attachForm=([control, "left", 1],
+                                    [control, "right", 1]))
diff --git a/openpype/hosts/maya/api/lib.py b/openpype/hosts/maya/api/lib.py
index 0b05182bb1..c2a140548a 100644
--- a/openpype/hosts/maya/api/lib.py
+++ b/openpype/hosts/maya/api/lib.py
@@ -8,7 +8,6 @@ import math
 
 import json
 import logging
-import itertools
 import contextlib
 from collections import OrderedDict, defaultdict
 from math import ceil
@@ -267,8 +266,10 @@ def float_round(num, places=0, direction=ceil):
 
 def pairwise(iterable):
     """s -> (s0,s1), (s2,s3), (s4, s5), ..."""
+    from six.moves import zip
+
     a = iter(iterable)
-    return itertools.izip(a, a)
+    return zip(a, a)
 
 
 def export_alembic(nodes,
@@ -2986,7 +2987,27 @@ def set_colorspace():
     """
     project_name = os.getenv("AVALON_PROJECT")
     imageio = get_anatomy_settings(project_name)["imageio"]["maya"]
-    root_dict = imageio["colorManagementPreference"]
+
+    # Maya 2022+ introduces new OCIO v2 color management settings that
+    # can override the old color managenement preferences. OpenPype has
+    # separate settings for both so we fall back when necessary.
+    use_ocio_v2 = imageio["colorManagementPreference_v2"]["enabled"]
+    required_maya_version = 2022
+    maya_version = int(cmds.about(version=True))
+    maya_supports_ocio_v2 = maya_version >= required_maya_version
+    if use_ocio_v2 and not maya_supports_ocio_v2:
+        # Fallback to legacy behavior with a warning
+        log.warning("Color Management Preference v2 is enabled but not "
+                    "supported by current Maya version: {} (< {}). Falling "
+                    "back to legacy settings.".format(
+                        maya_version, required_maya_version)
+                    )
+        use_ocio_v2 = False
+
+    if use_ocio_v2:
+        root_dict = imageio["colorManagementPreference_v2"]
+    else:
+        root_dict = imageio["colorManagementPreference"]
 
     if not isinstance(root_dict, dict):
         msg = "set_colorspace(): argument should be dictionary"
@@ -2994,11 +3015,12 @@ def set_colorspace():
 
     log.debug(">> root_dict: {}".format(root_dict))
 
-    # first enable color management
+    # enable color management
     cmds.colorManagementPrefs(e=True, cmEnabled=True)
     cmds.colorManagementPrefs(e=True, ocioRulesEnabled=True)
 
-    # second set config path
+    # set config path
+    custom_ocio_config = False
     if root_dict.get("configFilePath"):
         unresolved_path = root_dict["configFilePath"]
         ocio_paths = unresolved_path[platform.system().lower()]
@@ -3015,16 +3037,50 @@ def set_colorspace():
             cmds.colorManagementPrefs(e=True, cmConfigFileEnabled=True)
             log.debug("maya '{}' changed to: {}".format(
                 "configFilePath", resolved_path))
-            root_dict.pop("configFilePath")
+            custom_ocio_config = True
         else:
             cmds.colorManagementPrefs(e=True, cmConfigFileEnabled=False)
-            cmds.colorManagementPrefs(e=True, configFilePath="" )
+            cmds.colorManagementPrefs(e=True, configFilePath="")
 
-    # third set rendering space and view transform
-    renderSpace = root_dict["renderSpace"]
-    cmds.colorManagementPrefs(e=True, renderingSpaceName=renderSpace)
-    viewTransform = root_dict["viewTransform"]
-    cmds.colorManagementPrefs(e=True, viewTransformName=viewTransform)
+    # If no custom OCIO config file was set we make sure that Maya 2022+
+    # either chooses between Maya's newer default v2 or legacy config based
+    # on OpenPype setting to use ocio v2 or not.
+    if maya_supports_ocio_v2 and not custom_ocio_config:
+        if use_ocio_v2:
+            # Use Maya 2022+ default OCIO v2 config
+            log.info("Setting default Maya OCIO v2 config")
+            cmds.colorManagementPrefs(edit=True, configFilePath="")
+        else:
+            # Set the Maya default config file path
+            log.info("Setting default Maya OCIO v1 legacy config")
+            cmds.colorManagementPrefs(edit=True, configFilePath="legacy")
+
+    # set color spaces for rendering space and view transforms
+    def _colormanage(**kwargs):
+        """Wrapper around `cmds.colorManagementPrefs`.
+
+        This logs errors instead of raising an error so color management
+        settings get applied as much as possible.
+
+        """
+        assert len(kwargs) == 1, "Must receive one keyword argument"
+        try:
+            cmds.colorManagementPrefs(edit=True, **kwargs)
+            log.debug("Setting Color Management Preference: {}".format(kwargs))
+        except RuntimeError as exc:
+            log.error(exc)
+
+    if use_ocio_v2:
+        _colormanage(renderingSpaceName=root_dict["renderSpace"])
+        _colormanage(displayName=root_dict["displayName"])
+        _colormanage(viewName=root_dict["viewName"])
+    else:
+        _colormanage(renderingSpaceName=root_dict["renderSpace"])
+        if maya_supports_ocio_v2:
+            _colormanage(viewName=root_dict["viewTransform"])
+            _colormanage(displayName="legacy")
+        else:
+            _colormanage(viewTransformName=root_dict["viewTransform"])
 
 
 @contextlib.contextmanager
diff --git a/openpype/hosts/maya/plugins/create/create_render.py b/openpype/hosts/maya/plugins/create/create_render.py
index 97a190d57d..743ec26778 100644
--- a/openpype/hosts/maya/plugins/create/create_render.py
+++ b/openpype/hosts/maya/plugins/create/create_render.py
@@ -253,7 +253,7 @@ class CreateRender(plugin.Creator):
         # get pools
         pool_names = []
 
-        self.server_aliases = self.deadline_servers.keys()
+        self.server_aliases = list(self.deadline_servers.keys())
         self.data["deadlineServers"] = self.server_aliases
         self.data["suspendPublishJob"] = False
         self.data["review"] = True
@@ -286,15 +286,12 @@ class CreateRender(plugin.Creator):
             raise RuntimeError("Both Deadline and Muster are enabled")
 
         if deadline_enabled:
-            # if default server is not between selected, use first one for
-            # initial list of pools.
             try:
                 deadline_url = self.deadline_servers["default"]
             except KeyError:
-                deadline_url = [
-                    self.deadline_servers[k]
-                    for k in self.deadline_servers.keys()
-                ][0]
+                # if 'default' server is not between selected,
+                # use first one for initial list of pools.
+                deadline_url = next(iter(self.deadline_servers.values()))
 
             pool_names = self._get_deadline_pools(deadline_url)
 
diff --git a/openpype/hosts/maya/plugins/publish/collect_look.py b/openpype/hosts/maya/plugins/publish/collect_look.py
index d39750e917..b6a76f1e21 100644
--- a/openpype/hosts/maya/plugins/publish/collect_look.py
+++ b/openpype/hosts/maya/plugins/publish/collect_look.py
@@ -320,7 +320,7 @@ class CollectLook(pyblish.api.InstancePlugin):
 
         # Collect file nodes used by shading engines (if we have any)
         files = []
-        look_sets = sets.keys()
+        look_sets = list(sets.keys())
         shader_attrs = [
             "surfaceShader",
             "volumeShader",
diff --git a/openpype/hosts/maya/plugins/publish/collect_render.py b/openpype/hosts/maya/plugins/publish/collect_render.py
index 13ae1924b9..d99e81573b 100644
--- a/openpype/hosts/maya/plugins/publish/collect_render.py
+++ b/openpype/hosts/maya/plugins/publish/collect_render.py
@@ -234,13 +234,14 @@ class CollectMayaRender(pyblish.api.ContextPlugin):
             publish_meta_path = None
             for aov in exp_files:
                 full_paths = []
-                for file in aov[aov.keys()[0]]:
+                aov_first_key = list(aov.keys())[0]
+                for file in aov[aov_first_key]:
                     full_path = os.path.join(workspace, default_render_file,
                                              file)
                     full_path = full_path.replace("\\", "/")
                     full_paths.append(full_path)
                     publish_meta_path = os.path.dirname(full_path)
-                aov_dict[aov.keys()[0]] = full_paths
+                aov_dict[aov_first_key] = full_paths
 
             frame_start_render = int(self.get_render_attribute(
                 "startFrame", layer=layer_name))
diff --git a/openpype/hosts/maya/plugins/publish/extract_camera_mayaScene.py b/openpype/hosts/maya/plugins/publish/extract_camera_mayaScene.py
index 9d25b147de..3015b1ac24 100644
--- a/openpype/hosts/maya/plugins/publish/extract_camera_mayaScene.py
+++ b/openpype/hosts/maya/plugins/publish/extract_camera_mayaScene.py
@@ -43,7 +43,8 @@ def grouper(iterable, n, fillvalue=None):
 
     """
     args = [iter(iterable)] * n
-    return itertools.izip_longest(fillvalue=fillvalue, *args)
+    from six.moves import zip_longest
+    return zip_longest(fillvalue=fillvalue, *args)
 
 
 def unlock(plug):
diff --git a/openpype/hosts/maya/plugins/publish/extract_look.py b/openpype/hosts/maya/plugins/publish/extract_look.py
index fe89038a24..a9a2a7b60c 100644
--- a/openpype/hosts/maya/plugins/publish/extract_look.py
+++ b/openpype/hosts/maya/plugins/publish/extract_look.py
@@ -4,6 +4,7 @@ import os
 import sys
 import json
 import tempfile
+import platform
 import contextlib
 import subprocess
 from collections import OrderedDict
@@ -62,6 +63,11 @@ def maketx(source, destination, *args):
     from openpype.lib import get_oiio_tools_path
 
     maketx_path = get_oiio_tools_path("maketx")
+
+    if platform.system().lower() == "windows":
+        # Ensure .exe extension
+        maketx_path += ".exe"
+
     if not os.path.exists(maketx_path):
         print(
             "OIIO tool not found in {}".format(maketx_path))
@@ -216,7 +222,7 @@ class ExtractLook(openpype.api.Extractor):
         self.log.info("Extract sets (%s) ..." % _scene_type)
         lookdata = instance.data["lookData"]
         relationships = lookdata["relationships"]
-        sets = relationships.keys()
+        sets = list(relationships.keys())
         if not sets:
             self.log.info("No sets found")
             return
diff --git a/openpype/hosts/maya/plugins/publish/validate_ass_relative_paths.py b/openpype/hosts/maya/plugins/publish/validate_ass_relative_paths.py
index 3625d4ab32..5fb9bd98b1 100644
--- a/openpype/hosts/maya/plugins/publish/validate_ass_relative_paths.py
+++ b/openpype/hosts/maya/plugins/publish/validate_ass_relative_paths.py
@@ -110,9 +110,9 @@ class ValidateAssRelativePaths(pyblish.api.InstancePlugin):
         Maya API will return a list of values, which need to be properly
         handled to evaluate properly.
         """
-        if isinstance(attr_val, types.BooleanType):
+        if isinstance(attr_val, bool):
             return attr_val
-        elif isinstance(attr_val, (types.ListType, types.GeneratorType)):
+        elif isinstance(attr_val, (list, types.GeneratorType)):
             return any(attr_val)
         else:
             return bool(attr_val)
diff --git a/openpype/hosts/maya/plugins/publish/validate_mesh_overlapping_uvs.py b/openpype/hosts/maya/plugins/publish/validate_mesh_overlapping_uvs.py
index 5ce422239d..bf95d8ba09 100644
--- a/openpype/hosts/maya/plugins/publish/validate_mesh_overlapping_uvs.py
+++ b/openpype/hosts/maya/plugins/publish/validate_mesh_overlapping_uvs.py
@@ -5,6 +5,8 @@ import math
 import maya.api.OpenMaya as om
 import pymel.core as pm
 
+from six.moves import xrange
+
 
 class GetOverlappingUVs(object):
 
diff --git a/openpype/hosts/maya/plugins/publish/validate_vray_referenced_aovs.py b/openpype/hosts/maya/plugins/publish/validate_vray_referenced_aovs.py
index 6cfbd4049b..7a48c29b7d 100644
--- a/openpype/hosts/maya/plugins/publish/validate_vray_referenced_aovs.py
+++ b/openpype/hosts/maya/plugins/publish/validate_vray_referenced_aovs.py
@@ -82,9 +82,9 @@ class ValidateVrayReferencedAOVs(pyblish.api.InstancePlugin):
             bool: cast Maya attribute to Pythons boolean value.
 
         """
-        if isinstance(attr_val, types.BooleanType):
+        if isinstance(attr_val, bool):
             return attr_val
-        elif isinstance(attr_val, (types.ListType, types.GeneratorType)):
+        elif isinstance(attr_val, (list, types.GeneratorType)):
             return any(attr_val)
         else:
             return bool(attr_val)
diff --git a/openpype/settings/defaults/project_anatomy/imageio.json b/openpype/settings/defaults/project_anatomy/imageio.json
index 4a1496fe1a..1c86509155 100644
--- a/openpype/settings/defaults/project_anatomy/imageio.json
+++ b/openpype/settings/defaults/project_anatomy/imageio.json
@@ -177,6 +177,17 @@
         }
     },
     "maya": {
+        "colorManagementPreference_v2": {
+            "enabled": true,
+            "configFilePath": {
+                "windows": [],
+                "darwin": [],
+                "linux": []
+            },
+            "renderSpace": "ACEScg",
+            "viewName": "ACES 1.0 SDR-video",
+            "displayName": "sRGB"
+        },
         "colorManagementPreference": {
             "configFilePath": {
                 "windows": [],
diff --git a/openpype/settings/defaults/system_settings/applications.json b/openpype/settings/defaults/system_settings/applications.json
index 2f99200a88..0fb99a2608 100644
--- a/openpype/settings/defaults/system_settings/applications.json
+++ b/openpype/settings/defaults/system_settings/applications.json
@@ -93,7 +93,7 @@
                 }
             },
             "__dynamic_keys_labels__": {
-                "2022": "2022 (Testing Only)"
+                "2022": "2022"
             }
         }
     },
diff --git a/openpype/settings/entities/schemas/projects_schema/schemas/schema_anatomy_imageio.json b/openpype/settings/entities/schemas/projects_schema/schemas/schema_anatomy_imageio.json
index e000adacb0..3bec19c3d0 100644
--- a/openpype/settings/entities/schemas/projects_schema/schemas/schema_anatomy_imageio.json
+++ b/openpype/settings/entities/schemas/projects_schema/schemas/schema_anatomy_imageio.json
@@ -377,11 +377,47 @@
             "type": "dict",
             "label": "Maya",
             "children": [
+                {
+                    "key": "colorManagementPreference_v2",
+                    "type": "dict",
+                    "label": "Color Management Preference v2 (Maya 2022+)",
+                    "collapsible": true,
+                    "checkbox_key": "enabled",
+                    "children": [
+                        {
+                            "type": "boolean",
+                            "key": "enabled",
+                            "label": "Use Color Management Preference v2"
+                        },
+                        {
+                            "type": "path",
+                            "key": "configFilePath",
+                            "label": "OCIO Config File Path",
+                            "multiplatform": true,
+                            "multipath": true
+                        },
+                        {
+                            "type": "text",
+                            "key": "renderSpace",
+                            "label": "Rendering Space"
+                        },
+                        {
+                            "type": "text",
+                            "key": "displayName",
+                            "label": "Display"
+                        },
+                        {
+                            "type": "text",
+                            "key": "viewName",
+                            "label": "View"
+                        }
+                    ]
+                },
                 {
                     "key": "colorManagementPreference",
                     "type": "dict",
-                    "label": "Color Managment Preference",
-                    "collapsible": false,
+                    "label": "Color Management Preference (legacy)",
+                    "collapsible": true,
                     "children": [
                         {
                             "type": "path",
@@ -401,7 +437,7 @@
                             "label": "Viewer Transform"
                         }
                     ]
-            }
+                }
             ]
         },
         {
diff --git a/repos/avalon-core b/repos/avalon-core
index 159d2f23e4..ffe9e910f1 160000
--- a/repos/avalon-core
+++ b/repos/avalon-core
@@ -1 +1 @@
-Subproject commit 159d2f23e4c79c04dfac57b68d2ee6ac67adec1b
+Subproject commit ffe9e910f1f382e222d457d8e4a8426c41ed43ae