diff --git a/openpype/hosts/substancepainter/__init__.py b/openpype/hosts/substancepainter/__init__.py
new file mode 100644
index 0000000000..4c33b9f507
--- /dev/null
+++ b/openpype/hosts/substancepainter/__init__.py
@@ -0,0 +1,10 @@
+from .addon import (
+    SubstanceAddon,
+    SUBSTANCE_HOST_DIR,
+)
+
+
+__all__ = (
+    "SubstanceAddon",
+    "SUBSTANCE_HOST_DIR"
+)
diff --git a/openpype/hosts/substancepainter/addon.py b/openpype/hosts/substancepainter/addon.py
new file mode 100644
index 0000000000..bb55f20189
--- /dev/null
+++ b/openpype/hosts/substancepainter/addon.py
@@ -0,0 +1,34 @@
+import os
+from openpype.modules import OpenPypeModule, IHostAddon
+
+SUBSTANCE_HOST_DIR = os.path.dirname(os.path.abspath(__file__))
+
+
+class SubstanceAddon(OpenPypeModule, IHostAddon):
+    name = "substancepainter"
+    host_name = "substancepainter"
+
+    def initialize(self, module_settings):
+        self.enabled = True
+
+    def add_implementation_envs(self, env, _app):
+        # Add requirements to SUBSTANCE_PAINTER_PLUGINS_PATH
+        plugin_path = os.path.join(SUBSTANCE_HOST_DIR, "deploy")
+        plugin_path = plugin_path.replace("\\", "/")
+        if env.get("SUBSTANCE_PAINTER_PLUGINS_PATH"):
+            plugin_path += os.pathsep + env["SUBSTANCE_PAINTER_PLUGINS_PATH"]
+
+        env["SUBSTANCE_PAINTER_PLUGINS_PATH"] = plugin_path
+
+        # Fix UI scale issue
+        env.pop("QT_AUTO_SCREEN_SCALE_FACTOR", None)
+
+    def get_launch_hook_paths(self, app):
+        if app.host_name != self.host_name:
+            return []
+        return [
+            os.path.join(SUBSTANCE_HOST_DIR, "hooks")
+        ]
+
+    def get_workfile_extensions(self):
+        return [".spp", ".toc"]
diff --git a/openpype/hosts/substancepainter/api/__init__.py b/openpype/hosts/substancepainter/api/__init__.py
new file mode 100644
index 0000000000..937d0c429e
--- /dev/null
+++ b/openpype/hosts/substancepainter/api/__init__.py
@@ -0,0 +1,8 @@
+from .pipeline import (
+    SubstanceHost,
+
+)
+
+__all__ = [
+    "SubstanceHost",
+]
diff --git a/openpype/hosts/substancepainter/api/pipeline.py b/openpype/hosts/substancepainter/api/pipeline.py
new file mode 100644
index 0000000000..3fd081ca1c
--- /dev/null
+++ b/openpype/hosts/substancepainter/api/pipeline.py
@@ -0,0 +1,234 @@
+# -*- coding: utf-8 -*-
+"""Pipeline tools for OpenPype Gaffer integration."""
+import os
+import sys
+import logging
+from functools import partial
+
+# Substance 3D Painter modules
+import substance_painter.ui
+import substance_painter.event
+import substance_painter.export
+import substance_painter.project
+import substance_painter.textureset
+
+from openpype.host import HostBase, IWorkfileHost, ILoadHost, IPublishHost
+
+import pyblish.api
+
+from openpype.pipeline import (
+    register_creator_plugin_path,
+    register_loader_plugin_path,
+    AVALON_CONTAINER_ID
+)
+from openpype.lib import (
+    register_event_callback,
+    emit_event,
+)
+from openpype.pipeline.load import any_outdated_containers
+from openpype.hosts.substancepainter import SUBSTANCE_HOST_DIR
+
+log = logging.getLogger("openpype.hosts.substance")
+
+PLUGINS_DIR = os.path.join(SUBSTANCE_HOST_DIR, "plugins")
+PUBLISH_PATH = os.path.join(PLUGINS_DIR, "publish")
+LOAD_PATH = os.path.join(PLUGINS_DIR, "load")
+CREATE_PATH = os.path.join(PLUGINS_DIR, "create")
+INVENTORY_PATH = os.path.join(PLUGINS_DIR, "inventory")
+
+self = sys.modules[__name__]
+self.menu = None
+self.callbacks = []
+
+
+class SubstanceHost(HostBase, IWorkfileHost, ILoadHost, IPublishHost):
+    name = "substancepainter"
+
+    def __init__(self):
+        super(SubstanceHost, self).__init__()
+        self._has_been_setup = False
+
+    def install(self):
+        pyblish.api.register_host("substancepainter")
+
+        pyblish.api.register_plugin_path(PUBLISH_PATH)
+        register_loader_plugin_path(LOAD_PATH)
+        register_creator_plugin_path(CREATE_PATH)
+
+        log.info("Installing callbacks ... ")
+        # register_event_callback("init", on_init)
+        _register_callbacks()
+        # register_event_callback("before.save", before_save)
+        # register_event_callback("save", on_save)
+        register_event_callback("open", on_open)
+        # register_event_callback("new", on_new)
+
+        log.info("Installing menu ... ")
+        _install_menu()
+
+        self._has_been_setup = True
+
+    def uninstall(self):
+        _uninstall_menu()
+        _deregister_callbacks()
+
+    def has_unsaved_changes(self):
+
+        if not substance_painter.project.is_open():
+            return False
+
+        return substance_painter.project.needs_saving()
+
+    def get_workfile_extensions(self):
+        return [".spp", ".toc"]
+
+    def save_workfile(self, dst_path=None):
+
+        if not substance_painter.project.is_open():
+            return False
+
+        if not dst_path:
+            dst_path = self.get_current_workfile()
+
+        full_save_mode = substance_painter.project.ProjectSaveMode.Full
+        substance_painter.project.save_as(dst_path, full_save_mode)
+
+        return dst_path
+
+    def open_workfile(self, filepath):
+
+        if not os.path.exists(filepath):
+            raise RuntimeError("File does not exist: {}".format(filepath))
+
+        # We must first explicitly close current project before opening another
+        if substance_painter.project.is_open():
+            substance_painter.project.close()
+
+        substance_painter.project.open(filepath)
+        return filepath
+
+    def get_current_workfile(self):
+        if not substance_painter.project.is_open():
+            return None
+
+        filepath = substance_painter.project.file_path()
+        if filepath.endswith(".spt"):
+            # When currently in a Substance Painter template assume our
+            # scene isn't saved. This can be the case directly after doing
+            # "New project", the path will then be the template used. This
+            # avoids Workfiles tool trying to save as .spt extension if the
+            # file hasn't been saved before.
+            return
+
+        return filepath
+
+    def get_containers(self):
+        return []
+
+    @staticmethod
+    def create_context_node():
+        pass
+
+    def update_context_data(self, data, changes):
+        pass
+
+    def get_context_data(self):
+        pass
+
+
+def _install_menu():
+    from PySide2 import QtWidgets
+    from openpype.tools.utils import host_tools
+
+    parent = substance_painter.ui.get_main_window()
+
+    menu = QtWidgets.QMenu("OpenPype")
+
+    action = menu.addAction("Load...")
+    action.triggered.connect(
+        lambda: host_tools.show_loader(parent=parent, use_context=True)
+    )
+
+    action = menu.addAction("Publish...")
+    action.triggered.connect(
+        lambda: host_tools.show_publisher(parent=parent)
+    )
+
+    action = menu.addAction("Manage...")
+    action.triggered.connect(
+        lambda: host_tools.show_scene_inventory(parent=parent)
+    )
+
+    action = menu.addAction("Library...")
+    action.triggered.connect(
+        lambda: host_tools.show_library_loader(parent=parent)
+    )
+
+    menu.addSeparator()
+    action = menu.addAction("Work Files...")
+    action.triggered.connect(
+        lambda: host_tools.show_workfiles(parent=parent)
+    )
+
+    substance_painter.ui.add_menu(menu)
+
+    def on_menu_destroyed():
+        self.menu = None
+
+    menu.destroyed.connect(on_menu_destroyed)
+
+    self.menu = menu
+
+
+def _uninstall_menu():
+    if self.menu:
+        self.menu.destroy()
+        self.menu = None
+
+
+def _register_callbacks():
+    # Prepare emit event callbacks
+    open_callback = partial(emit_event, "open")
+
+    # Connect to the Substance Painter events
+    dispatcher = substance_painter.event.DISPATCHER
+    for event, callback in [
+        (substance_painter.event.ProjectOpened, open_callback)
+    ]:
+        dispatcher.connect(event, callback)
+        # Keep a reference so we can deregister if needed
+        self.callbacks.append((event, callback))
+
+
+def _deregister_callbacks():
+    for event, callback in self.callbacks:
+        substance_painter.event.DISPATCHER.disconnect(event, callback)
+
+
+def on_open():
+    log.info("Running callback on open..")
+    print("Run")
+
+    if any_outdated_containers():
+        from openpype.widgets import popup
+
+        log.warning("Scene has outdated content.")
+
+        # Get main window
+        parent = substance_painter.ui.get_main_window()
+        if parent is None:
+            log.info("Skipping outdated content pop-up "
+                     "because Substance window can't be found.")
+        else:
+
+            # Show outdated pop-up
+            def _on_show_inventory():
+                from openpype.tools.utils import host_tools
+                host_tools.show_scene_inventory(parent=parent)
+
+            dialog = popup.Popup(parent=parent)
+            dialog.setWindowTitle("Substance scene has outdated content")
+            dialog.setMessage("There are outdated containers in "
+                              "your Substance scene.")
+            dialog.on_clicked.connect(_on_show_inventory)
+            dialog.show()
\ No newline at end of file
diff --git a/openpype/hosts/substancepainter/deploy/plugins/openpype_plugin.py b/openpype/hosts/substancepainter/deploy/plugins/openpype_plugin.py
new file mode 100644
index 0000000000..01779156f1
--- /dev/null
+++ b/openpype/hosts/substancepainter/deploy/plugins/openpype_plugin.py
@@ -0,0 +1,15 @@
+
+def start_plugin():
+    from openpype.pipeline import install_host
+    from openpype.hosts.substancepainter.api import SubstanceHost
+
+    install_host(SubstanceHost())
+
+
+def close_plugin():
+    from openpype.pipeline import uninstall_host
+    uninstall_host()
+
+
+if __name__ == "__main__":
+    start_plugin()
diff --git a/openpype/resources/app_icons/substancepainter.png b/openpype/resources/app_icons/substancepainter.png
new file mode 100644
index 0000000000..dc46f25d74
Binary files /dev/null and b/openpype/resources/app_icons/substancepainter.png differ
diff --git a/openpype/settings/defaults/system_settings/applications.json b/openpype/settings/defaults/system_settings/applications.json
index 936407a49b..30c692d0e6 100644
--- a/openpype/settings/defaults/system_settings/applications.json
+++ b/openpype/settings/defaults/system_settings/applications.json
@@ -1315,6 +1315,33 @@
             }
         }
     },
+    "substance": {
+        "enabled": true,
+        "label": "Substance Painter",
+        "icon": "app_icons/substancepainter.png",
+        "host_name": "substancepainter",
+        "environment": {},
+        "variants": {
+            "8-2-0": {
+                "executables": {
+                    "windows": [
+                        "C:\\Program Files\\Adobe\\Adobe Substance 3D Painter\\Adobe Substance 3D Painter.exe"
+                    ],
+                    "darwin": [],
+                    "linux": []
+                },
+                "arguments": {
+                    "windows": [],
+                    "darwin": [],
+                    "linux": []
+                },
+                "environment": {}
+            },
+            "__dynamic_keys_labels__": {
+                "8-2-0": "8.2.0"
+            }
+        }
+    },
     "unreal": {
         "enabled": true,
         "label": "Unreal Editor",
diff --git a/openpype/settings/entities/enum_entity.py b/openpype/settings/entities/enum_entity.py
index c0c103ea10..de3bd353eb 100644
--- a/openpype/settings/entities/enum_entity.py
+++ b/openpype/settings/entities/enum_entity.py
@@ -168,6 +168,7 @@ class HostsEnumEntity(BaseEnumEntity):
         "tvpaint",
         "unreal",
         "standalonepublisher",
+        "substancepainter",
         "traypublisher",
         "webpublisher"
     ]
diff --git a/openpype/settings/entities/schemas/system_schema/host_settings/schema_substancepainter.json b/openpype/settings/entities/schemas/system_schema/host_settings/schema_substancepainter.json
new file mode 100644
index 0000000000..513f98c610
--- /dev/null
+++ b/openpype/settings/entities/schemas/system_schema/host_settings/schema_substancepainter.json
@@ -0,0 +1,40 @@
+{
+    "type": "dict",
+    "key": "substance",
+    "label": "Substance Painter",
+    "collapsible": true,
+    "checkbox_key": "enabled",
+    "children": [
+        {
+            "type": "boolean",
+            "key": "enabled",
+            "label": "Enabled"
+        },
+        {
+            "type": "schema_template",
+            "name": "template_host_unchangables"
+        },
+        {
+            "key": "environment",
+            "label": "Environment",
+            "type": "raw-json"
+        },
+        {
+            "type": "dict-modifiable",
+            "key": "variants",
+            "collapsible_key": true,
+            "use_label_wrap": false,
+            "object_type": {
+                "type": "dict",
+                "collapsible": true,
+                "children": [
+                    {
+                        "type": "schema_template",
+                        "name": "template_host_variant_items",
+                        "skip_paths": ["use_python_2"]
+                    }
+                ]
+            }
+        }
+    ]
+}
diff --git a/openpype/settings/entities/schemas/system_schema/schema_applications.json b/openpype/settings/entities/schemas/system_schema/schema_applications.json
index 36c5811496..06a805086a 100644
--- a/openpype/settings/entities/schemas/system_schema/schema_applications.json
+++ b/openpype/settings/entities/schemas/system_schema/schema_applications.json
@@ -85,6 +85,10 @@
       "type": "schema",
       "name": "schema_celaction"
     },
+    {
+      "type": "schema",
+      "name": "schema_substancepainter"
+    },
     {
       "type": "schema",
       "name": "schema_unreal"