diff --git a/client/ayon_core/tools/tray/tray.py b/client/ayon_core/tools/tray/tray.py
index eca87eb11d..c0b90dd764 100644
--- a/client/ayon_core/tools/tray/tray.py
+++ b/client/ayon_core/tools/tray/tray.py
@@ -182,7 +182,27 @@ class TrayManager:
         }:
             envs.pop(key, None)
 
+        # Remove any existing addon path from 'PYTHONPATH'
+        addons_dir = os.environ.get("AYON_ADDONS_DIR", "")
+        if addons_dir:
+            addons_dir = os.path.normpath(addons_dir)
+        addons_dir = addons_dir.lower()
+
+        pythonpath = envs.get("PYTHONPATH") or ""
+        new_python_paths = []
+        for path in pythonpath.split(os.pathsep):
+            if not path:
+                continue
+            path = os.path.normpath(path)
+            if path.lower().startswith(addons_dir):
+                continue
+            new_python_paths.append(path)
+
+        envs["PYTHONPATH"] = os.pathsep.join(new_python_paths)
+
+        # Start new process
         run_detached_process(args, env=envs)
+        # Exit current tray process
         self.exit()
 
     def exit(self):