diff --git a/client/ayon_core/addon/base.py b/client/ayon_core/addon/base.py
index b9ecff4233..308494b4d8 100644
--- a/client/ayon_core/addon/base.py
+++ b/client/ayon_core/addon/base.py
@@ -9,9 +9,8 @@ import logging
 import threading
 import collections
 from uuid import uuid4
-from abc import ABCMeta, abstractmethod
+from abc import ABC, abstractmethod
 
-import six
 import appdirs
 import ayon_api
 from semver import VersionInfo
@@ -499,8 +498,7 @@ def is_func_marked(func):
     return getattr(func, _MARKING_ATTR, False)
 
 
-@six.add_metaclass(ABCMeta)
-class AYONAddon(object):
+class AYONAddon(ABC):
     """Base class of AYON addon.
 
     Attributes:
diff --git a/client/ayon_core/addon/interfaces.py b/client/ayon_core/addon/interfaces.py
index 86e0c6e060..b273e7839b 100644
--- a/client/ayon_core/addon/interfaces.py
+++ b/client/ayon_core/addon/interfaces.py
@@ -1,7 +1,5 @@
 from abc import ABCMeta, abstractmethod
 
-import six
-
 from ayon_core import resources
 
 
@@ -15,8 +13,7 @@ class _AYONInterfaceMeta(ABCMeta):
         return str(self)
 
 
-@six.add_metaclass(_AYONInterfaceMeta)
-class AYONInterface:
+class AYONInterface(metaclass=_AYONInterfaceMeta):
     """Base class of Interface that can be used as Mixin with abstract parts.
 
     This is way how AYON addon can define that contains specific predefined
diff --git a/client/ayon_core/host/dirmap.py b/client/ayon_core/host/dirmap.py
index b90b414240..19841845e7 100644
--- a/client/ayon_core/host/dirmap.py
+++ b/client/ayon_core/host/dirmap.py
@@ -7,18 +7,15 @@ exists is used.
 """
 
 import os
-from abc import ABCMeta, abstractmethod
+from abc import ABC, abstractmethod
 import platform
 
-import six
-
 from ayon_core.lib import Logger
 from ayon_core.addon import AddonsManager
 from ayon_core.settings import get_project_settings
 
 
-@six.add_metaclass(ABCMeta)
-class HostDirmap(object):
+class HostDirmap(ABC):
     """Abstract class for running dirmap on a workfile in a host.
 
     Dirmap is used to translate paths inside of host workfile from one
diff --git a/client/ayon_core/host/host.py b/client/ayon_core/host/host.py
index 081aafdbe3..5a29de6cd7 100644
--- a/client/ayon_core/host/host.py
+++ b/client/ayon_core/host/host.py
@@ -1,15 +1,13 @@
 import os
 import logging
 import contextlib
-from abc import ABCMeta, abstractproperty
-import six
+from abc import ABC, abstractproperty
 
 # NOTE can't import 'typing' because of issues in Maya 2020
 #   - shiboken crashes on 'typing' module import
 
 
-@six.add_metaclass(ABCMeta)
-class HostBase(object):
+class HostBase(ABC):
     """Base of host implementation class.
 
     Host is pipeline implementation of DCC application. This class should help
diff --git a/client/ayon_core/host/interfaces.py b/client/ayon_core/host/interfaces.py
index 7157ad6f7e..c077dfeae9 100644
--- a/client/ayon_core/host/interfaces.py
+++ b/client/ayon_core/host/interfaces.py
@@ -1,5 +1,4 @@
-from abc import ABCMeta, abstractmethod
-import six
+from abc import ABC, abstractmethod
 
 
 class MissingMethodsError(ValueError):
@@ -106,8 +105,7 @@ class ILoadHost:
         return self.get_containers()
 
 
-@six.add_metaclass(ABCMeta)
-class IWorkfileHost:
+class IWorkfileHost(ABC):
     """Implementation requirements to be able use workfile utils and tool."""
 
     @staticmethod
diff --git a/client/ayon_core/lib/attribute_definitions.py b/client/ayon_core/lib/attribute_definitions.py
index 0a9d38ab65..360d47ea17 100644
--- a/client/ayon_core/lib/attribute_definitions.py
+++ b/client/ayon_core/lib/attribute_definitions.py
@@ -6,7 +6,6 @@ import json
 import copy
 from abc import ABCMeta, abstractmethod, abstractproperty
 
-import six
 import clique
 
 # Global variable which store attribute definitions by type
@@ -91,8 +90,7 @@ class AbstractAttrDefMeta(ABCMeta):
         return obj
 
 
-@six.add_metaclass(AbstractAttrDefMeta)
-class AbstractAttrDef(object):
+class AbstractAttrDef(metaclass=AbstractAttrDefMeta):
     """Abstraction of attribute definition.
 
     Each attribute definition must have implemented validation and
@@ -349,7 +347,7 @@ class NumberDef(AbstractAttrDef):
         )
 
     def convert_value(self, value):
-        if isinstance(value, six.string_types):
+        if isinstance(value, str):
             try:
                 value = float(value)
             except Exception:
@@ -396,12 +394,12 @@ class TextDef(AbstractAttrDef):
         if multiline is None:
             multiline = False
 
-        elif not isinstance(default, six.string_types):
+        elif not isinstance(default, str):
             raise TypeError((
-                "'default' argument must be a {}, not '{}'"
-            ).format(six.string_types, type(default)))
+                f"'default' argument must be a str, not '{type(default)}'"
+            ))
 
-        if isinstance(regex, six.string_types):
+        if isinstance(regex, str):
             regex = re.compile(regex)
 
         self.multiline = multiline
@@ -418,7 +416,7 @@ class TextDef(AbstractAttrDef):
         )
 
     def convert_value(self, value):
-        if isinstance(value, six.string_types):
+        if isinstance(value, str):
             return value
         return self.default
 
@@ -736,7 +734,7 @@ class FileDefItem(object):
                 else:
                     output.append(item)
 
-            elif isinstance(item, six.string_types):
+            elif isinstance(item, str):
                 str_filepaths.append(item)
             else:
                 raise TypeError(
@@ -844,7 +842,7 @@ class FileDef(AbstractAttrDef):
                 if isinstance(default, dict):
                     FileDefItem.from_dict(default)
 
-                elif isinstance(default, six.string_types):
+                elif isinstance(default, str):
                     default = FileDefItem.from_paths([default.strip()])[0]
 
                 else:
@@ -883,14 +881,14 @@ class FileDef(AbstractAttrDef):
         )
 
     def convert_value(self, value):
-        if isinstance(value, six.string_types) or isinstance(value, dict):
+        if isinstance(value, (str, dict)):
             value = [value]
 
         if isinstance(value, (tuple, list, set)):
             string_paths = []
             dict_items = []
             for item in value:
-                if isinstance(item, six.string_types):
+                if isinstance(item, str):
                     string_paths.append(item.strip())
                 elif isinstance(item, dict):
                     try:
diff --git a/client/ayon_core/lib/file_transaction.py b/client/ayon_core/lib/file_transaction.py
index 81a3b386f6..47b10dd994 100644
--- a/client/ayon_core/lib/file_transaction.py
+++ b/client/ayon_core/lib/file_transaction.py
@@ -2,7 +2,6 @@ import os
 import logging
 import sys
 import errno
-import six
 
 from ayon_core.lib import create_hard_link
 
@@ -158,11 +157,13 @@ class FileTransaction(object):
 
     def rollback(self):
         errors = 0
+        last_exc = None
         # Rollback any transferred files
         for path in self._transferred:
             try:
                 os.remove(path)
-            except OSError:
+            except OSError as exc:
+                last_exc = exc
                 errors += 1
                 self.log.error(
                     "Failed to rollback created file: {}".format(path),
@@ -172,7 +173,8 @@ class FileTransaction(object):
         for backup, original in self._backup_to_original.items():
             try:
                 os.rename(backup, original)
-            except OSError:
+            except OSError as exc:
+                last_exc = exc
                 errors += 1
                 self.log.error(
                     "Failed to restore original file: {} -> {}".format(
@@ -183,7 +185,7 @@ class FileTransaction(object):
             self.log.error(
                 "{} errors occurred during rollback.".format(errors),
                 exc_info=True)
-            six.reraise(*sys.exc_info())
+            raise last_exc
 
     @property
     def transferred(self):
@@ -200,11 +202,9 @@ class FileTransaction(object):
         try:
             os.makedirs(dirname)
         except OSError as e:
-            if e.errno == errno.EEXIST:
-                pass
-            else:
+            if e.errno != errno.EEXIST:
                 self.log.critical("An unexpected error occurred.")
-                six.reraise(*sys.exc_info())
+                raise e
 
     def _same_paths(self, src, dst):
         # handles same paths but with C:/project vs c:/project
diff --git a/client/ayon_core/lib/local_settings.py b/client/ayon_core/lib/local_settings.py
index fd255c997f..54432265d9 100644
--- a/client/ayon_core/lib/local_settings.py
+++ b/client/ayon_core/lib/local_settings.py
@@ -4,7 +4,7 @@ import os
 import json
 import platform
 from datetime import datetime
-from abc import ABCMeta, abstractmethod
+from abc import ABC, abstractmethod
 
 # disable lru cache in Python 2
 try:
@@ -24,7 +24,6 @@ try:
 except ImportError:
     import ConfigParser as configparser
 
-import six
 import appdirs
 import ayon_api
 
@@ -133,8 +132,7 @@ class AYONSecureRegistry:
         keyring.delete_password(self._name, name)
 
 
-@six.add_metaclass(ABCMeta)
-class ASettingRegistry():
+class ASettingRegistry(ABC):
     """Abstract class defining structure of **SettingRegistry** class.
 
     It is implementing methods to store secure items into keyring, otherwise
diff --git a/client/ayon_core/lib/path_templates.py b/client/ayon_core/lib/path_templates.py
index a766dbd9c1..01a6985a25 100644
--- a/client/ayon_core/lib/path_templates.py
+++ b/client/ayon_core/lib/path_templates.py
@@ -2,8 +2,6 @@ import os
 import re
 import numbers
 
-import six
-
 KEY_PATTERN = re.compile(r"(\{.*?[^{0]*\})")
 KEY_PADDING_PATTERN = re.compile(r"([^:]+)\S+[><]\S+")
 SUB_DICT_PATTERN = re.compile(r"([^\[\]]+)")
@@ -14,7 +12,7 @@ class TemplateUnsolved(Exception):
     """Exception for unsolved template when strict is set to True."""
 
     msg = "Template \"{0}\" is unsolved.{1}{2}"
-    invalid_types_msg = " Keys with invalid DataType: `{0}`."
+    invalid_types_msg = " Keys with invalid data type: `{0}`."
     missing_keys_msg = " Missing keys: \"{0}\"."
 
     def __init__(self, template, missing_keys, invalid_types):
@@ -43,7 +41,7 @@ class TemplateUnsolved(Exception):
 class StringTemplate(object):
     """String that can be formatted."""
     def __init__(self, template):
-        if not isinstance(template, six.string_types):
+        if not isinstance(template, str):
             raise TypeError("<{}> argument must be a string, not {}.".format(
                 self.__class__.__name__, str(type(template))
             ))
@@ -63,7 +61,7 @@ class StringTemplate(object):
 
         new_parts = []
         for part in parts:
-            if not isinstance(part, six.string_types):
+            if not isinstance(part, str):
                 new_parts.append(part)
                 continue
 
@@ -113,7 +111,7 @@ class StringTemplate(object):
         """
         result = TemplatePartResult()
         for part in self._parts:
-            if isinstance(part, six.string_types):
+            if isinstance(part, str):
                 result.add_output(part)
             else:
                 part.format(data, result)
@@ -176,7 +174,7 @@ class StringTemplate(object):
                         value = "<>"
                     elif (
                         len(parts) == 1
-                        and isinstance(parts[0], six.string_types)
+                        and isinstance(parts[0], str)
                     ):
                         value = "<{}>".format(parts[0])
                     else:
@@ -200,8 +198,9 @@ class StringTemplate(object):
                 new_parts.extend(tmp_parts[idx])
         return new_parts
 
+
 class TemplateResult(str):
-    """Result of template format with most of information in.
+    """Result of template format with most of the information in.
 
     Args:
         used_values (dict): Dictionary of template filling data with
@@ -299,7 +298,7 @@ class TemplatePartResult:
         self._optional = True
 
     def add_output(self, other):
-        if isinstance(other, six.string_types):
+        if isinstance(other, str):
             self._output += other
 
         elif isinstance(other, TemplatePartResult):
@@ -457,7 +456,7 @@ class FormattingPart:
             return True
 
         for inh_class in type(value).mro():
-            if inh_class in six.string_types:
+            if inh_class is str:
                 return True
         return False
 
@@ -568,7 +567,7 @@ class OptionalPart:
     def format(self, data, result):
         new_result = TemplatePartResult(True)
         for part in self._parts:
-            if isinstance(part, six.string_types):
+            if isinstance(part, str):
                 new_result.add_output(part)
             else:
                 part.format(data, new_result)
diff --git a/client/ayon_core/pipeline/create/creator_plugins.py b/client/ayon_core/pipeline/create/creator_plugins.py
index 0e6025ad3b..624f1c9588 100644
--- a/client/ayon_core/pipeline/create/creator_plugins.py
+++ b/client/ayon_core/pipeline/create/creator_plugins.py
@@ -3,9 +3,7 @@ import copy
 import collections
 from typing import TYPE_CHECKING, Optional
 
-from abc import ABCMeta, abstractmethod
-
-import six
+from abc import ABC, abstractmethod
 
 from ayon_core.settings import get_project_settings
 from ayon_core.lib import Logger
@@ -38,8 +36,7 @@ class CreatorError(Exception):
         super(CreatorError, self).__init__(message)
 
 
-@six.add_metaclass(ABCMeta)
-class ProductConvertorPlugin(object):
+class ProductConvertorPlugin(ABC):
     """Helper for conversion of instances created using legacy creators.
 
     Conversion from legacy creators would mean to lose legacy instances,
@@ -152,8 +149,7 @@ class ProductConvertorPlugin(object):
         self._create_context.remove_convertor_item(self.identifier)
 
 
-@six.add_metaclass(ABCMeta)
-class BaseCreator:
+class BaseCreator(ABC):
     """Plugin that create and modify instance data before publishing process.
 
     We should maybe find better name as creation is only one part of its logic
diff --git a/client/ayon_core/pipeline/project_folders.py b/client/ayon_core/pipeline/project_folders.py
index 811a98ce4b..902b969457 100644
--- a/client/ayon_core/pipeline/project_folders.py
+++ b/client/ayon_core/pipeline/project_folders.py
@@ -2,8 +2,6 @@ import os
 import re
 import json
 
-import six
-
 from ayon_core.settings import get_project_settings
 from ayon_core.lib import Logger
 
@@ -109,6 +107,6 @@ def get_project_basic_paths(project_name):
     if not folder_structure:
         return []
 
-    if isinstance(folder_structure, six.string_types):
+    if isinstance(folder_structure, str):
         folder_structure = json.loads(folder_structure)
     return _list_path_items(folder_structure)
diff --git a/client/ayon_core/pipeline/publish/abstract_collect_render.py b/client/ayon_core/pipeline/publish/abstract_collect_render.py
index 17cab876b6..bd2d76c39c 100644
--- a/client/ayon_core/pipeline/publish/abstract_collect_render.py
+++ b/client/ayon_core/pipeline/publish/abstract_collect_render.py
@@ -7,8 +7,6 @@ TODO: use @dataclass when times come.
 from abc import abstractmethod
 
 import attr
-import six
-
 import pyblish.api
 
 from .publish_plugins import AbstractMetaContextPlugin
@@ -122,8 +120,9 @@ class RenderInstance(object):
             raise ValueError("both tiles X a Y sizes are set to 1")
 
 
-@six.add_metaclass(AbstractMetaContextPlugin)
-class AbstractCollectRender(pyblish.api.ContextPlugin):
+class AbstractCollectRender(
+    pyblish.api.ContextPlugin, metaclass=AbstractMetaContextPlugin
+):
     """Gather all publishable render layers from renderSetup."""
 
     order = pyblish.api.CollectorOrder + 0.01
diff --git a/client/ayon_core/pipeline/publish/abstract_expected_files.py b/client/ayon_core/pipeline/publish/abstract_expected_files.py
index f9f3c17ef5..fffe723739 100644
--- a/client/ayon_core/pipeline/publish/abstract_expected_files.py
+++ b/client/ayon_core/pipeline/publish/abstract_expected_files.py
@@ -1,11 +1,9 @@
 # -*- coding: utf-8 -*-
 """Abstract ExpectedFile class definition."""
-from abc import ABCMeta, abstractmethod
-import six
+from abc import ABC, abstractmethod
 
 
-@six.add_metaclass(ABCMeta)
-class ExpectedFiles:
+class ExpectedFiles(ABC):
     """Class grouping functionality for all supported renderers.
 
     Attributes:
diff --git a/client/ayon_core/pipeline/schema/__init__.py b/client/ayon_core/pipeline/schema/__init__.py
index db98a6d080..d16755696d 100644
--- a/client/ayon_core/pipeline/schema/__init__.py
+++ b/client/ayon_core/pipeline/schema/__init__.py
@@ -17,7 +17,6 @@ import json
 import logging
 
 import jsonschema
-import six
 
 log_ = logging.getLogger(__name__)
 
@@ -44,7 +43,7 @@ def validate(data, schema=None):
 
     root, schema = data["schema"].rsplit(":", 1)
 
-    if isinstance(schema, six.string_types):
+    if isinstance(schema, str):
         schema = _cache[schema + ".json"]
 
     resolver = jsonschema.RefResolver(
diff --git a/client/ayon_core/pipeline/workfile/workfile_template_builder.py b/client/ayon_core/pipeline/workfile/workfile_template_builder.py
index 467a24a52f..7b15dff049 100644
--- a/client/ayon_core/pipeline/workfile/workfile_template_builder.py
+++ b/client/ayon_core/pipeline/workfile/workfile_template_builder.py
@@ -15,9 +15,8 @@ import os
 import re
 import collections
 import copy
-from abc import ABCMeta, abstractmethod
+from abc import ABC, abstractmethod
 
-import six
 from ayon_api import (
     get_folders,
     get_folder_by_path,
@@ -82,8 +81,7 @@ class TemplateLoadFailed(Exception):
     pass
 
 
-@six.add_metaclass(ABCMeta)
-class AbstractTemplateBuilder(object):
+class AbstractTemplateBuilder(ABC):
     """Abstraction of Template Builder.
 
     Builder cares about context, shared data, cache, discovery of plugins
@@ -941,8 +939,7 @@ class AbstractTemplateBuilder(object):
         )
 
 
-@six.add_metaclass(ABCMeta)
-class PlaceholderPlugin(object):
+class PlaceholderPlugin(ABC):
     """Plugin which care about handling of placeholder items logic.
 
     Plugin create and update placeholders in scene and populate them on
diff --git a/client/ayon_core/plugins/load/delete_old_versions.py b/client/ayon_core/plugins/load/delete_old_versions.py
index 62302e7123..f8c45baff6 100644
--- a/client/ayon_core/plugins/load/delete_old_versions.py
+++ b/client/ayon_core/plugins/load/delete_old_versions.py
@@ -1,6 +1,7 @@
 import collections
 import os
 import uuid
+from typing import List, Dict, Any
 
 import clique
 import ayon_api
@@ -41,11 +42,13 @@ class DeleteOldVersions(load.ProductLoaderPlugin):
         )
     ]
 
+    requires_confirmation = True
+
     def delete_whole_dir_paths(self, dir_paths, delete=True):
         size = 0
 
         for dir_path in dir_paths:
-            # Delete all files and fodlers in dir path
+            # Delete all files and folders in dir path
             for root, dirs, files in os.walk(dir_path, topdown=False):
                 for name in files:
                     file_path = os.path.join(root, name)
@@ -192,6 +195,42 @@ class DeleteOldVersions(load.ProductLoaderPlugin):
         )
         msgBox.exec_()
 
+    def _confirm_delete(self,
+                        contexts: List[Dict[str, Any]],
+                        versions_to_keep: int) -> bool:
+        """Prompt user for a deletion confirmation"""
+
+        contexts_list = "\n".join(sorted(
+            "- {folder[name]} > {product[name]}".format_map(context)
+            for context in contexts
+        ))
+        num_contexts = len(contexts)
+        s = "s" if num_contexts > 1 else ""
+        text = (
+            "Are you sure you want to delete versions?\n\n"
+            f"This will keep only the last {versions_to_keep} "
+            f"versions for the {num_contexts} selected product{s}."
+        )
+        informative_text="Warning: This will delete files from disk"
+        detailed_text = (
+            f"Keep only {versions_to_keep} versions for:\n{contexts_list}"
+        )
+
+        messagebox = QtWidgets.QMessageBox()
+        messagebox.setIcon(QtWidgets.QMessageBox.Warning)
+        messagebox.setWindowTitle("Delete Old Versions")
+        messagebox.setText(text)
+        messagebox.setInformativeText(informative_text)
+        messagebox.setDetailedText(detailed_text)
+        messagebox.setStandardButtons(
+            QtWidgets.QMessageBox.Yes
+            | QtWidgets.QMessageBox.Cancel
+        )
+        messagebox.setDefaultButton(QtWidgets.QMessageBox.Cancel)
+        messagebox.setStyleSheet(style.load_stylesheet())
+        messagebox.setAttribute(QtCore.Qt.WA_DeleteOnClose, True)
+        return messagebox.exec_() == QtWidgets.QMessageBox.Yes
+
     def get_data(self, context, versions_count):
         product_entity = context["product"]
         folder_entity = context["folder"]
@@ -365,19 +404,29 @@ class DeleteOldVersions(load.ProductLoaderPlugin):
         return size
 
     def load(self, contexts, name=None, namespace=None, options=None):
+
+        # Get user options
+        versions_to_keep = 2
+        remove_publish_folder = False
+        if options:
+            versions_to_keep = options.get(
+                "versions_to_keep", versions_to_keep
+            )
+            remove_publish_folder = options.get(
+                "remove_publish_folder", remove_publish_folder
+            )
+
+        # Because we do not want this run by accident we will add an extra
+        # user confirmation
+        if (
+                self.requires_confirmation
+                and not self._confirm_delete(contexts, versions_to_keep)
+        ):
+            return
+
         try:
             size = 0
             for count, context in enumerate(contexts):
-                versions_to_keep = 2
-                remove_publish_folder = False
-                if options:
-                    versions_to_keep = options.get(
-                        "versions_to_keep", versions_to_keep
-                    )
-                    remove_publish_folder = options.get(
-                        "remove_publish_folder", remove_publish_folder
-                    )
-
                 data = self.get_data(context, versions_to_keep)
                 if not data:
                     continue
@@ -408,6 +457,8 @@ class CalculateOldVersions(DeleteOldVersions):
         )
     ]
 
+    requires_confirmation = False
+
     def main(self, project_name, data, remove_publish_folder):
         size = 0
 
diff --git a/client/ayon_core/plugins/publish/extract_burnin.py b/client/ayon_core/plugins/publish/extract_burnin.py
index 93774842ca..58a032a030 100644
--- a/client/ayon_core/plugins/publish/extract_burnin.py
+++ b/client/ayon_core/plugins/publish/extract_burnin.py
@@ -6,7 +6,6 @@ import platform
 import shutil
 
 import clique
-import six
 import pyblish.api
 
 from ayon_core import resources, AYON_CORE_ROOT
@@ -456,7 +455,7 @@ class ExtractBurnin(publish.Extractor):
             sys_name = platform.system().lower()
             font_filepath = font_filepath.get(sys_name)
 
-        if font_filepath and isinstance(font_filepath, six.string_types):
+        if font_filepath and isinstance(font_filepath, str):
             font_filepath = font_filepath.format(**os.environ)
             if not os.path.exists(font_filepath):
                 font_filepath = None
diff --git a/client/ayon_core/plugins/publish/extract_review.py b/client/ayon_core/plugins/publish/extract_review.py
index 1891c25521..c2793f98a2 100644
--- a/client/ayon_core/plugins/publish/extract_review.py
+++ b/client/ayon_core/plugins/publish/extract_review.py
@@ -4,9 +4,8 @@ import copy
 import json
 import shutil
 import subprocess
-from abc import ABCMeta, abstractmethod
+from abc import ABC, abstractmethod
 
-import six
 import clique
 import speedcopy
 import pyblish.api
@@ -1661,8 +1660,7 @@ class ExtractReview(pyblish.api.InstancePlugin):
         return vf_back
 
 
-@six.add_metaclass(ABCMeta)
-class _OverscanValue:
+class _OverscanValue(ABC):
     def __repr__(self):
         return "<{}> {}".format(self.__class__.__name__, str(self))
 
diff --git a/client/ayon_core/plugins/publish/integrate.py b/client/ayon_core/plugins/publish/integrate.py
index 2da33bfb19..a2cf910fa6 100644
--- a/client/ayon_core/plugins/publish/integrate.py
+++ b/client/ayon_core/plugins/publish/integrate.py
@@ -4,7 +4,6 @@ import sys
 import copy
 
 import clique
-import six
 import pyblish.api
 from ayon_api import (
     get_attributes_for_type,
@@ -160,15 +159,14 @@ class IntegrateAsset(pyblish.api.InstancePlugin):
             # Raise DuplicateDestinationError as KnownPublishError
             # and rollback the transactions
             file_transactions.rollback()
-            six.reraise(KnownPublishError,
-                        KnownPublishError(exc),
-                        sys.exc_info()[2])
-        except Exception:
+            raise KnownPublishError(exc).with_traceback(sys.exc_info()[2])
+
+        except Exception as exc:
             # clean destination
             # todo: preferably we'd also rollback *any* changes to the database
             file_transactions.rollback()
             self.log.critical("Error when registering", exc_info=True)
-            six.reraise(*sys.exc_info())
+            raise exc
 
         # Finalizing can't rollback safely so no use for moving it to
         # the try, except.
diff --git a/client/ayon_core/style/__init__.py b/client/ayon_core/style/__init__.py
index 8d3089ef86..064f527f2b 100644
--- a/client/ayon_core/style/__init__.py
+++ b/client/ayon_core/style/__init__.py
@@ -2,7 +2,6 @@ import os
 import copy
 import json
 import collections
-import six
 
 from ayon_core import resources
 
@@ -75,7 +74,7 @@ def _convert_color_values_to_objects(value):
             output[_key] = _convert_color_values_to_objects(_value)
         return output
 
-    if not isinstance(value, six.string_types):
+    if not isinstance(value, str):
         raise TypeError((
             "Unexpected type in colors data '{}'. Expected 'str' or 'dict'."
         ).format(str(type(value))))
diff --git a/client/ayon_core/tools/common_models/hierarchy.py b/client/ayon_core/tools/common_models/hierarchy.py
index f92563db20..6bccb0f468 100644
--- a/client/ayon_core/tools/common_models/hierarchy.py
+++ b/client/ayon_core/tools/common_models/hierarchy.py
@@ -1,18 +1,16 @@
 import time
 import collections
 import contextlib
-from abc import ABCMeta, abstractmethod
+from abc import ABC, abstractmethod
 
 import ayon_api
-import six
 
 from ayon_core.lib import NestedCacheItem
 
 HIERARCHY_MODEL_SENDER = "hierarchy.model"
 
 
-@six.add_metaclass(ABCMeta)
-class AbstractHierarchyController:
+class AbstractHierarchyController(ABC):
     @abstractmethod
     def emit_event(self, topic, data, source):
         pass
diff --git a/client/ayon_core/tools/launcher/abstract.py b/client/ayon_core/tools/launcher/abstract.py
index 921fe7bc5b..63ba4cd717 100644
--- a/client/ayon_core/tools/launcher/abstract.py
+++ b/client/ayon_core/tools/launcher/abstract.py
@@ -1,10 +1,7 @@
-from abc import ABCMeta, abstractmethod
-
-import six
+from abc import ABC, abstractmethod
 
 
-@six.add_metaclass(ABCMeta)
-class AbstractLauncherCommon(object):
+class AbstractLauncherCommon(ABC):
     @abstractmethod
     def register_event_callback(self, topic, callback):
         """Register event callback.
diff --git a/client/ayon_core/tools/loader/abstract.py b/client/ayon_core/tools/loader/abstract.py
index 3a1a23edd7..6a68af1eb5 100644
--- a/client/ayon_core/tools/loader/abstract.py
+++ b/client/ayon_core/tools/loader/abstract.py
@@ -1,5 +1,4 @@
-from abc import ABCMeta, abstractmethod
-import six
+from abc import ABC, abstractmethod
 
 from ayon_core.lib.attribute_definitions import (
     AbstractAttrDef,
@@ -347,8 +346,7 @@ class ActionItem:
         return cls(**data)
 
 
-@six.add_metaclass(ABCMeta)
-class _BaseLoaderController(object):
+class _BaseLoaderController(ABC):
     """Base loader controller abstraction.
 
     Abstract base class that is required for both frontend and backed.
diff --git a/client/ayon_core/tools/publisher/publish_report_viewer/window.py b/client/ayon_core/tools/publisher/publish_report_viewer/window.py
index 3ee986e6f7..aedc3b9e31 100644
--- a/client/ayon_core/tools/publisher/publish_report_viewer/window.py
+++ b/client/ayon_core/tools/publisher/publish_report_viewer/window.py
@@ -1,6 +1,5 @@
 import os
 import json
-import six
 import uuid
 
 import appdirs
@@ -387,7 +386,7 @@ class LoadedFilesModel(QtGui.QStandardItemModel):
         if not filepaths:
             return
 
-        if isinstance(filepaths, six.string_types):
+        if isinstance(filepaths, str):
             filepaths = [filepaths]
 
         filtered_paths = []
diff --git a/client/ayon_core/tools/workfiles/abstract.py b/client/ayon_core/tools/workfiles/abstract.py
index e949915ab2..b78e987032 100644
--- a/client/ayon_core/tools/workfiles/abstract.py
+++ b/client/ayon_core/tools/workfiles/abstract.py
@@ -1,7 +1,6 @@
 import os
-from abc import ABCMeta, abstractmethod
+from abc import ABC, abstractmethod
 
-import six
 from ayon_core.style import get_default_entity_icon_color
 
 
@@ -335,8 +334,7 @@ class WorkareaFilepathResult:
         self.filepath = filepath
 
 
-@six.add_metaclass(ABCMeta)
-class AbstractWorkfilesCommon(object):
+class AbstractWorkfilesCommon(ABC):
     @abstractmethod
     def is_host_valid(self):
         """Host is valid for workfiles tool work.