diff --git a/openpype/hooks/pre_python_2_prelaunch.py b/openpype/hooks/pre_python_2_prelaunch.py
index d6b1fe57a5..84272d2e5d 100644
--- a/openpype/hooks/pre_python_2_prelaunch.py
+++ b/openpype/hooks/pre_python_2_prelaunch.py
@@ -4,12 +4,12 @@ from openpype.lib import PreLaunchHook
 
 class PrePython2Vendor(PreLaunchHook):
     """Prepend python 2 dependencies for py2 hosts."""
-    # WARNING This hook will probably be deprecated in OpenPype 3 - kept for
-    # test
     order = 10
-    app_groups = ["hiero", "nuke", "nukex", "maya", "houdini"]
 
     def execute(self):
+        if not self.application.use_python_2:
+            return
+
         # Prepare vendor dir path
         self.log.info("adding global python 2 vendor")
         pype_root = os.getenv("OPENPYPE_REPOS_ROOT")
diff --git a/openpype/lib/applications.py b/openpype/lib/applications.py
index 51c646d494..730d4230b6 100644
--- a/openpype/lib/applications.py
+++ b/openpype/lib/applications.py
@@ -179,6 +179,7 @@ class Application:
         if group.enabled:
             enabled = data.get("enabled", True)
         self.enabled = enabled
+        self.use_python_2 = data["use_python_2"]
 
         self.label = data.get("variant_label") or name
         self.full_name = "/".join((group.name, name))
diff --git a/openpype/modules/ftrack/launch_hooks/pre_python2_vendor.py b/openpype/modules/ftrack/launch_hooks/pre_python2_vendor.py
index 7826d833ac..d34b6533fb 100644
--- a/openpype/modules/ftrack/launch_hooks/pre_python2_vendor.py
+++ b/openpype/modules/ftrack/launch_hooks/pre_python2_vendor.py
@@ -8,10 +8,13 @@ class PrePython2Support(PreLaunchHook):
 
     Path to vendor modules is added to the beggining of PYTHONPATH.
     """
-    # There will be needed more granular filtering in future
-    app_groups = ["maya", "nuke", "nukex", "hiero", "nukestudio"]
 
     def execute(self):
+        if not self.application.use_python_2:
+            return
+
+        self.log.info("Adding Ftrack Python 2 packages to PYTHONPATH.")
+
         # Prepare vendor dir path
         python_2_vendor = os.path.join(FTRACK_MODULE_DIR, "python2_vendor")
 
diff --git a/openpype/settings/defaults/system_settings/applications.json b/openpype/settings/defaults/system_settings/applications.json
index e7e934e1ea..2355f39aa1 100644
--- a/openpype/settings/defaults/system_settings/applications.json
+++ b/openpype/settings/defaults/system_settings/applications.json
@@ -20,6 +20,7 @@
         },
         "variants": {
             "2022": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Autodesk\\Maya2022\\bin\\maya.exe"
@@ -39,6 +40,7 @@
                 }
             },
             "2020": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Autodesk\\Maya2020\\bin\\maya.exe"
@@ -58,6 +60,7 @@
                 }
             },
             "2019": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Autodesk\\Maya2019\\bin\\maya.exe"
@@ -77,6 +80,7 @@
                 }
             },
             "2018": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Autodesk\\Maya2018\\bin\\maya.exe"
@@ -118,6 +122,7 @@
         },
         "variants": {
             "13-0": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke13.0v1\\Nuke13.0.exe"
@@ -135,6 +140,7 @@
                 "environment": {}
             },
             "12-2": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke12.2v3\\Nuke12.2.exe"
@@ -152,6 +158,7 @@
                 "environment": {}
             },
             "12-0": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke12.0v1\\Nuke12.0.exe"
@@ -169,6 +176,7 @@
                 "environment": {}
             },
             "11-3": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke11.3v1\\Nuke11.3.exe"
@@ -186,6 +194,7 @@
                 "environment": {}
             },
             "11-2": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke11.2v2\\Nuke11.2.exe"
@@ -227,6 +236,7 @@
         },
         "variants": {
             "13-0": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke13.0v1\\Nuke13.0.exe"
@@ -250,6 +260,7 @@
                 "environment": {}
             },
             "12-2": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke12.2v3\\Nuke12.2.exe"
@@ -273,6 +284,7 @@
                 "environment": {}
             },
             "12-0": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke12.0v1\\Nuke12.0.exe"
@@ -296,6 +308,7 @@
                 "environment": {}
             },
             "11-3": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke11.3v1\\Nuke11.3.exe"
@@ -319,6 +332,7 @@
                 "environment": {}
             },
             "11-2": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke11.2v2\\Nuke11.2.exe"
@@ -366,6 +380,7 @@
         },
         "variants": {
             "13-0": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke13.0v1\\Nuke13.0.exe"
@@ -389,6 +404,7 @@
                 "environment": {}
             },
             "12-2": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke12.2v3\\Nuke12.2.exe"
@@ -412,6 +428,7 @@
                 "environment": {}
             },
             "12-0": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke12.0v1\\Nuke12.0.exe"
@@ -435,6 +452,7 @@
                 "environment": {}
             },
             "11-3": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke11.3v1\\Nuke11.3.exe"
@@ -458,6 +476,7 @@
                 "environment": {}
             },
             "11-2": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -503,6 +522,7 @@
         },
         "variants": {
             "13-0": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke13.0v1\\Nuke13.0.exe"
@@ -526,6 +546,7 @@
                 "environment": {}
             },
             "12-2": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke12.2v3\\Nuke12.2.exe"
@@ -549,6 +570,7 @@
                 "environment": {}
             },
             "12-0": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke12.0v1\\Nuke12.0.exe"
@@ -572,6 +594,7 @@
                 "environment": {}
             },
             "11-3": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke11.3v1\\Nuke11.3.exe"
@@ -595,6 +618,7 @@
                 "environment": {}
             },
             "11-2": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Nuke11.2v2\\Nuke11.2.exe"
@@ -657,6 +681,7 @@
             "16": {
                 "enabled": true,
                 "variant_label": "16",
+                "use_python_2": false,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -672,6 +697,7 @@
             "9": {
                 "enabled": true,
                 "variant_label": "9",
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Blackmagic Design\\Fusion 9\\Fusion.exe"
@@ -735,6 +761,7 @@
             "16": {
                 "enabled": true,
                 "variant_label": "16",
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:/Program Files/Blackmagic Design/DaVinci Resolve/Resolve.exe"
@@ -770,6 +797,7 @@
         },
         "variants": {
             "18-5": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Side Effects Software\\Houdini 18.5.499\\bin\\houdini.exe"
@@ -785,6 +813,7 @@
                 "environment": {}
             },
             "18": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -798,6 +827,7 @@
                 "environment": {}
             },
             "17": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -832,6 +862,7 @@
         },
         "variants": {
             "2-83": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Blender Foundation\\Blender 2.83\\blender.exe"
@@ -853,6 +884,7 @@
                 "environment": {}
             },
             "2-90": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Blender Foundation\\Blender 2.90\\blender.exe"
@@ -874,6 +906,7 @@
                 "environment": {}
             },
             "2-91": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Blender Foundation\\Blender 2.91\\blender.exe"
@@ -914,6 +947,7 @@
             "20": {
                 "enabled": true,
                 "variant_label": "20",
+                "use_python_2": false,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -929,6 +963,7 @@
             "17": {
                 "enabled": true,
                 "variant_label": "17",
+                "use_python_2": false,
                 "executables": {
                     "windows": [],
                     "darwin": [
@@ -955,6 +990,7 @@
         },
         "variants": {
             "animation_11-64bits": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\TVPaint Developpement\\TVPaint Animation 11 (64bits)\\TVPaint Animation 11 (64bits).exe"
@@ -970,6 +1006,7 @@
                 "environment": {}
             },
             "animation_11-32bits": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files (x86)\\TVPaint Developpement\\TVPaint Animation 11 (32bits)\\TVPaint Animation 11 (32bits).exe"
@@ -1005,6 +1042,7 @@
             "2020": {
                 "enabled": true,
                 "variant_label": "2020",
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Adobe\\Adobe Photoshop 2020\\Photoshop.exe"
@@ -1022,6 +1060,7 @@
             "2021": {
                 "enabled": true,
                 "variant_label": "2021",
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Adobe\\Adobe Photoshop 2021\\Photoshop.exe"
@@ -1053,6 +1092,7 @@
             "2020": {
                 "enabled": true,
                 "variant_label": "2020",
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         ""
@@ -1070,6 +1110,7 @@
             "2021": {
                 "enabled": true,
                 "variant_label": "2021",
+                "use_python_2": false,
                 "executables": {
                     "windows": [
                         "C:\\Program Files\\Adobe\\Adobe After Effects 2021\\Support Files\\AfterFX.exe"
@@ -1098,6 +1139,7 @@
             "local": {
                 "enabled": true,
                 "variant_label": "Local",
+                "use_python_2": false,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -1142,6 +1184,7 @@
         "environment": {},
         "variants": {
             "python_3-7": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -1155,6 +1198,7 @@
                 "environment": {}
             },
             "python_2-7": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -1168,6 +1212,7 @@
                 "environment": {}
             },
             "terminal": {
+                "use_python_2": true,
                 "executables": {
                     "windows": [],
                     "darwin": [],
@@ -1194,6 +1239,7 @@
         "environment": {},
         "variants": {
             "1-1": {
+                "use_python_2": false,
                 "executables": {
                     "windows": [],
                     "darwin": [],
diff --git a/openpype/settings/entities/input_entities.py b/openpype/settings/entities/input_entities.py
index e406c7797a..e897576d43 100644
--- a/openpype/settings/entities/input_entities.py
+++ b/openpype/settings/entities/input_entities.py
@@ -376,7 +376,10 @@ class BoolEntity(InputEntity):
 
     def _item_initalization(self):
         self.valid_value_types = (bool, )
-        self.value_on_not_set = True
+        value_on_not_set = self.convert_to_valid_type(
+            self.schema_data.get("default", True)
+        )
+        self.value_on_not_set = value_on_not_set
 
 
 class TextEntity(InputEntity):
diff --git a/openpype/settings/entities/schemas/system_schema/host_settings/template_host_variant_items.json b/openpype/settings/entities/schemas/system_schema/host_settings/template_host_variant_items.json
index bba4634c46..472840d8fc 100644
--- a/openpype/settings/entities/schemas/system_schema/host_settings/template_host_variant_items.json
+++ b/openpype/settings/entities/schemas/system_schema/host_settings/template_host_variant_items.json
@@ -1,4 +1,10 @@
 [
+    {
+        "type": "boolean",
+        "key": "use_python_2",
+        "label": "Use Python 2",
+        "default": false
+    },
     {
         "type": "path",
         "key": "executables",